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Combination effecst of metal and fluoride on inhibiting demineralization and collagen degradation in dentin

Research Project

Project/Area Number 25462949
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Nakashima Syozi  東京医科歯科大学, 歯学部, 非常勤講師 (90571282)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords根面う蝕 / サホライド / フッ化亜鉛 / 脱灰抑制 / コラーゲン分解抑制 / 根面う蝕の予防 / う蝕予防 / コラーゲン分解 / 亜鉛化合物 / ハイドロキシプロリン / コラゲナーゼ / 象牙質う蝕 / フッ化物 / 脱灰 / コラーゲン
Outline of Final Research Achievements

This study aimed to develope a new topical fluoride agent for root caries prevention which has anti-demineralization and anti-collagen degradation without discoloration of root surface. Silver diammine fluoride (SDF) or Saforide has an excellent root caries preventive efficacy, but it causes severe browing of root surface and gingiva as a drawback. This study tried to employ ZnF2 as an alternative of SDF. ZnF2 is less soluble in water, and thus was solubilized by adding a minimum amount of HCl (ZnF2/HCl).
Present results revealed that ZnF2/HCl demonstrated similar anti-demineralization efficacy to SDF in spite of less fluoride concentration (1/5 compared to SDF), but insufficient anti-collagen degradation efficacy was noted comparing to that of SDF. No observable discoloration was noted on the treated surface by ZnF2/HCl. Further study is needed to improve the anti-collagen degradation efficacy by increasing the concentration and treatment time.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results) Presentation (3 results)

  • [Journal Article] Comparative study of demineralized collagen degradation determined by hydroxyproline assay and microscopic depth measurement.2016

    • Author(s)
      Islam MS, Khunkar SJ, Nakashima S, Sadr A, Nikaido T, Tagami J.
    • Journal Title

      J Dent.

      Volume: 47 Pages: 94-97

    • DOI

      10.1016/j.jdent.2016.01.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro dentine remineralization with a potential salivary phosphoprotein homologue.2016

    • Author(s)
      Romero MJ, Nakashima S, Nikaido T, Sadr A, Tagami J.
    • Journal Title

      Arch Oral Biol.

      Volume: 68 Pages: 35-42

    • DOI

      10.1016/j.archoralbio.2016.03.014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Adsorption Behavior of Methacryloyloxy Decyldihydrogen Phosphate on an Apatite Surface at Neutral pH.2016

    • Author(s)
      1.Bista B. Nakashima S, Nikaido T, Sadr Ali, Takagaki T, Maja Romero, Sato Takaaki, J Tagami.
    • Journal Title

      Eur J Oral Sci.

      Volume: 124 Issue: 2 Pages: 195-203

    • DOI

      10.1111/eos.12254

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Formation and characterization of hypermineralized zone beneath dentine lesion body induced by topical fluoride in-vitro.2015

    • Author(s)
      Khunkar SJ, Utaka S, Hariri I, Sadr A, Ikeda M, Nakashima S, Nikaido T, Tagami J.
    • Journal Title

      Arch Oral Biol.

      Volume: 60 Issue: 4 Pages: 574-581

    • DOI

      10.1016/j.archoralbio.2015.01.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Inhibition of hydroxyapatite growth by casein, a potential salivary phosphoprotein homologue.2015

    • Author(s)
      Romero MJ, Nakashima S, Nikaido T, Ichinose S, Sadr A, Tagami J.
    • Journal Title

      Eur J Oral Sci.

      Volume: 123 Issue: 4 Pages: 288-296

    • DOI

      10.1111/eos.12196

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] エナメル質臨界pHについての理論的考察2014

    • Author(s)
      中嶋省志、Sadr Alireza、田上順次
    • Journal Title

      日本歯科保存学雑誌

      Volume: 57 Pages: 111-120

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Comparative study of demineralized collagen degradation determined by hydroxyproline assay and microscopic depth measurement.2015

    • Author(s)
      Islam M, Khunkar S, Nakashima S, Sadr A, Nikaido T, Tagami J.
    • Organizer
      第143回日本歯科保存学会総会
    • Place of Presentation
      東京都文京区(文京シビックホール)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effect of zinc fluoride on inhibition of dentin demineralization and collagen degradation in-vitro2014

    • Author(s)
      Syozi Nakashima, et al.
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      山形市 山形テルサ
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] ZnF2による脱灰抑制およびコラーゲン分解抑制効果について2014

    • Author(s)
      中嶋省志
    • Organizer
      日本歯科保存学会(第141回秋大会)
    • Place of Presentation
      山形市
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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