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Study of the effects of serine proteases on the cariogenicity of Streptococcus mutans

Research Project

Project/Area Number 25462962
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

OZAKI Kazumi  徳島大学, 大学院医歯薬学研究部, 教授 (90214121)

Co-Investigator(Kenkyū-buntansha) YUMOTO Hiromichi  徳島大学, 病院, 講師 (60284303)
HOSOKAWA Yoshitaka  徳島大学, 大学院医歯薬学研究部, 助教 (90346601)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsバイオフィルム / クオラムセンシング / オートインデューサー
Outline of Final Research Achievements

The aim of this study was to evaluate the effect of the enzymes, which digest autoinducers, on the cariogenicity of Streptococcus mutans. Trypsin and rHtrA were tended to inhibit bacterial growth and the adherence of S.mutans to a glass test tube, furthermore, suppress biosynthesis of intra/extra-cellular polysaccharide in comparison with negative control. These results suggested that these enzymes will be able to exhibit antibacterial activities and inhibit biofilm formation by S.mutans.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014 2013

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (10 results)

  • [Journal Article] IL-4 modulates CCL11 and CCL20 productions from IL-1β-stimulated human periodontal ligament cells2016

    • Author(s)
      Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki, Takashi Matsuo
    • Journal Title

      Cellular Physiology and Biochemistry

      Volume: 38 Issue: 1 Pages: 153-159

    • DOI

      10.1159/000438617

    • NAID

      120006550808

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Calcitriol supressed inflammatory reactions in IL-1β-stimulated human periodontal ligament cells2015

    • Author(s)
      Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki, Takashi Matsuo
    • Journal Title

      Inflammation

      Volume: 38 Issue: 6 Pages: 2252-2258

    • DOI

      10.1007/s10753-015-0209-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IL-6 trans-signaling enhances CCL20 production from IL-1・-stimulated human periodontal ligament cells2014

    • Author(s)
      Hosokawa Y, Shindo S, Hosokawa I, Ozaki K, Matsuo T
    • Journal Title

      Inflammation

      Volume: 37(2) Issue: 2 Pages: 381-386

    • DOI

      10.1007/s10753-013-9750-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] IL-22 Enhances CCL20 Production in IL-1β-Stimulated Human Gingival Fibroblasts.2014

    • Author(s)
      Hosokawa Y, Hosokawa I, Shindo S, Ozaki K, Matsuo T.
    • Journal Title

      Inflammation

      Volume: 37 Issue: 6 Pages: 2062-2066

    • DOI

      10.1007/s10753-014-9939-5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genipin inhibits MMP-1 and MMP-3 release from TNF-α-stimulated human periodontal ligament cells.2014

    • Author(s)
      Shindo S, Hosokawa Y, Hosokawa I, Ozaki K, Matsuo T.
    • Journal Title

      Biochimie

      Volume: 107 Pages: 391-395

    • DOI

      10.1016/j.biochi.2014.10.008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genipin inhibits IL-1・-induced CCL20 and IL-6 production from human periodontal ligament cells2014

    • Author(s)
      Shindo S, Hosokawa Y, Hosokawa I, Ozaki K, Matsuo T
    • Journal Title

      Cell Physiol Biochem

      Volume: 33 Issue: 2 Pages: 357-364

    • DOI

      10.1159/000356675

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] TLR3 agonist enhances CC chemokine ligand 20 production in IL-1β-stimulated human gingival fibroblasts.2013

    • Author(s)
      Hosokawa Y, Hosokawa I, Shindo S, Ozaki K, Matsuo T.
    • Journal Title

      Cellular Immunology

      Volume: 283 Issue: 1-2 Pages: 8-11

    • DOI

      10.1016/j.cellimm.2013.05.005

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] (-)-Epigallocatechin-3-gallate inhibits CC chemokine ligand 11 production in human gingival fibroblasts2013

    • Author(s)
      Hosokawa Y, Hosokawa I, Shindo S, Ozaki K, Matsuo T
    • Journal Title

      Cell Physiol Biochem

      Volume: 31 Issue: 6 Pages: 960-967

    • DOI

      10.1159/000350114

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oral porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3β signaling pathway2013

    • Author(s)
      Ishikawa M, Yoshida K, Okamura H, Ochiai K, Takamura H, Fujiwara N, Ozaki K.
    • Journal Title

      Biochimica Biophysica Acta-Molecular Basis of Disease

      Volume: 1832 Issue: 12 Pages: 2035-2043

    • DOI

      10.1016/j.bbadis.2013.07.012

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] IL-4がヒト歯根膜由来細胞のCCL11およびCCL20産生に及ぼす影響2015

    • Author(s)
      細川義隆,細川育子,新藤 智,尾崎和美,松尾敬志
    • Organizer
      第58回秋季日本歯周病学会学術大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] PKRやインフラマソームがP.gingivalisを感染させた骨芽細胞において骨吸収に関連する因子の発現に与える影響2015

    • Author(s)
      吉田賀弥,岡村裕彦,尾崎和美
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] IL-4 Modulates Chemokine Productions From IL-1β-stimulated Human Periodontal Ligament Cells.2015

    • Author(s)
      Hosokawa Y., Hosokawa I, Shindo S., Ozaki K., Matsuo T.
    • Organizer
      The 2015 IADR/AADR/CADR General Session
    • Place of Presentation
      Hynes Convention Center (Boston, USA)
    • Year and Date
      2015-03-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Melatonin Inhibits Inflammatory Mediators Productions in Human Periodontal Ligament Cells.2015

    • Author(s)
      Hosokawa I, Hosokawa Y., Shindo S., Ozaki K., Matsuo T.
    • Organizer
      The 2015 IADR/AADR/CADR General Session
    • Place of Presentation
      Hynes Convention Center (Boston, USA)
    • Year and Date
      2015-03-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Shikoninがヒト歯根膜由来細胞のIL-6およびIL-8産生に与える影響2014

    • Author(s)
      新藤 智,細川 義隆,細川 育子,尾崎 和美,松尾 敬志
    • Organizer
      第141回日本歯科保存学会2014年度秋季学術大会
    • Place of Presentation
      山形テルサ(山形県山形市)
    • Year and Date
      2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] GenipinはE.coli LPSが誘導するヒト歯根膜細胞のIL-6およびIL-8産生を抑制する2014

    • Author(s)
      新藤 智,細川 義隆,細川 育子,尾崎 和美,松尾 敬志
    • Organizer
      第140回日本歯科保存学会2014年度春季学術大会
    • Place of Presentation
      滋賀県立芸術劇場びわ湖ホール(滋賀県大津市)
    • Year and Date
      2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 活性型ビタミンDはIL-1β刺激ヒト歯根膜細胞の炎症性サイトカイン産生を抑制する2014

    • Author(s)
      細川 義隆,細川 育子,新藤 智,尾崎 和美,松尾 敬志
    • Organizer
      第140回日本歯科保存学会2014年度春季学術大会
    • Place of Presentation
      滋賀県立芸術劇場びわ湖ホール(滋賀県大津市)
    • Year and Date
      2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] genipinはTNF-αが誘導するヒト歯根膜由来細胞のIL-6産生を抑制する2014

    • Author(s)
      北中祐太郎,細川義隆,細川育子,新藤 智,尾崎和美,松尾敬志
    • Organizer
      第57回春季日本歯周病学会学術大会
    • Place of Presentation
      長良川国際会議場(岐阜県岐阜市)
    • Year and Date
      2014-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] IL-6はIL-1βが誘導するヒト歯根膜由来細胞のCCL20産生を増強する2013

    • Author(s)
      細川義隆,細川育子,新藤 智,尾崎和美,松尾敬志
    • Organizer
      第56回春季日本歯周病学会学術大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] GenipinはIL-1betaが誘導するヒト歯根膜細胞のCCL20およびIL-6産生を抑制する2013

    • Author(s)
      新藤 智,細川義隆,細川育子,尾崎和美,松尾敬志
    • Organizer
      第139回日本歯科保存学会2013年度秋季学術大会
    • Place of Presentation
      秋田県総合生活文化会館(秋田県)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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