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Investigation of titanium allergy, elucidation and prevention methods

Research Project

Project/Area Number 25463003
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionThe University of Tokushima

Principal Investigator

HOSOKI Maki  徳島大学, 大学院医歯薬学研究部, 助教 (10228421)

Co-Investigator(Kenkyū-buntansha) NISHIGAWA Keisuke  徳島大学, 病院, 講師 (10202235)
YAMASHITA Kikuji  徳島大学, 大学院医歯薬学研究部, 准教授 (30182497)
TAJIMA Toyoko  徳島大学, 病院, 助教 (80335801)
MATSUKA Yoshizou  徳島大学, 大学院医歯薬学研究部, 教授 (90243477)
UEDA Mayu  徳島大学, 病院, 助教 (20625719)
TAKEUCHI Hisahiro  徳島大学, 病院, 講師 (10222093)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords金属アレルギー / チタン / アレルギー / 金属
Outline of Final Research Achievements

Although titanium is known to possess high bio-compatibility and used in various types of bio-materials. Recently, however, several studies have reported cases of allergic symptoms caused by titanium-containing materials.
We investigated the prevalence of titanium allergy from surveillance of individuals with suspected dental metal allergy. The results of this surveillance showed that titanium allergy exists, even if the number was small. We performed to establish a mouse model for the evaluation of titanium allergy.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014 Other

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) Book (1 results)

  • [Journal Article] Allergic contact dermatitis caused by titanium screws and dental implants2016

    • Author(s)
      Hosoki M, Nishigawa K, Miyamoto Y, Ohe G, Matsuka Y
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 60 Issue: 3 Pages: 213-219

    • DOI

      10.1016/j.jpor.2015.12.004

    • NAID

      130005172067

    • ISSN
      1883-1958, 1883-9207
    • Year and Date
      2016-07-25
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ニッケル含有ピアスによる金属アレルギー発症の危険性について2014

    • Author(s)
      細木 眞紀, 田島 登誉子, 西川 啓介, 竹内 久裕, 松香 芳三, 久保 宜明
    • Journal Title

      Journal of Environmental Dermatology and Cutaneous Allergology

      Volume: vol8,No1 Pages: 12-20

    • NAID

      40019971949

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 金属アレルギーと歯科2014

    • Author(s)
      細木 眞紀, 松香 芳三
    • Journal Title

      8020推進財団 会誌

      Volume: 13 Pages: 52-57

    • Related Report
      2014 Research-status Report
  • [Journal Article] ニッケル含有ピアスによる金属アレルギー発症の危険性について2014

    • Author(s)
      細木真紀,田島登誉子,西川啓介,竹内久裕,松香芳三,久保宜明
    • Journal Title

      日本皮膚アレルギー・接触皮膚炎学会雑誌

      Volume: Vol.8 No.1 Pages: 12-20

    • NAID

      40019971949

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] チタンアレルギーモデルマウスの作成について2016

    • Author(s)
      細木真紀
    • Organizer
      平成27年度第2回四国5大学連携女性研究者研究交流発表会
    • Place of Presentation
      エクシブ鳴門(徳島県・鳴門市)
    • Year and Date
      2016-02-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 経皮感作による金属アレルギーモデルマウスの作成,2015

    • Author(s)
      細木真紀
    • Organizer
      四国5大学連携女性研究者活躍推進シンポジウム2015
    • Place of Presentation
      徳島大学(徳島県・徳島市)
    • Year and Date
      2015-12-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 経皮感作による金属アレルギーモデルマウスの作成について2015

    • Author(s)
      細木眞紀, 久保宣明 , 田島登誉子, 松香芳三,
    • Organizer
      日本皮膚アレルギー・接触皮膚炎学会
    • Place of Presentation
      島根県民会館(島根県・松江市)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] ニッケルアレルギーモデルマウスの感作特性の検討2015

    • Author(s)
      福本美緒, 細木眞紀, 井上美穂, 西川啓介, 田島登誉子, 重本貴穂, 上枝麻友, 清水さとみ, 福田政司, 安村 博, 松香芳三
    • Organizer
      日本補綴歯科学会中国・四国支部学術大会
    • Place of Presentation
      くにびきメッセ(島根県・松江市)
    • Year and Date
      2015-09-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] ニッケルアレルギーモデルマウスの作製と炎症局所のサイトカイン活性について2015

    • Author(s)
      細木眞紀, 西川啓介, 大本勝弘, 上枝麻友, 田島登誉子, 松香芳三
    • Organizer
      日本補綴歯科学会
    • Place of Presentation
      大宮ソニックシティ(埼玉県・さいたま市)
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] チタン製歯科インプラントが関与したアレルギー性接触皮膚炎の1例2014

    • Author(s)
      細木真紀,田島登誉子,久保宜明
    • Organizer
      日本皮膚アレルギー・接触皮膚炎学会総会・学術大会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2014-11-21 – 2014-11-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Clinical Investigation of Titanium Allergy Prevalence2014

    • Author(s)
      Hosoki M, Tajima T, Nishigawa K, Ueda M, Matsuka Y
    • Organizer
      Indonesia Japan Prosthodontic Society Joint Meeting 2014
    • Place of Presentation
      Grand Nikko Bali(Bali・Indonesia)
    • Year and Date
      2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] ピアスと金属アレルギーー健常者を対象とした感作状況調査ー

    • Author(s)
      細木真紀,田島登誉子,久保宜明
    • Organizer
      第43回日本皮膚アレルギー・接触皮膚炎学会総会・学術大会
    • Place of Presentation
      ホテル日航金沢・石川
    • Related Report
      2013 Research-status Report
  • [Book] 歯界展望,Vol.126,No.5 金属アレルギーの臨床的対応の実際,2015

    • Author(s)
      細木 真紀
    • Total Pages
      208
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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