| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Outline of Final Research Achievements |
We prepared collagen/nano-apatite composites by blending, and implanted them in rat cranial defects. It became evident that sponge composites were absorbed, but pressed composites had good osteo-conductive properties, leading to much new bone formation. It was suggested that pressed collagen/nano-apatite composites are new bone substitute materials.
We also prepared crosslink-type hyaluronic acid/nano-apatite/BMP sols, and implanted them in mouse head, back and muscle. The materials (gel) induced bone formation at high rates. It was speculated that crosslink-type hyaluronic acid/nano-apatite/BMP composite might be used as safe injectable (sol-gel reaction type) osteo-cunductive medical device.
|
