Feasibility of Molecularly Targeted Therapy for Tooth Regeneration
Project/Area Number |
25463081
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Kyoto University |
Principal Investigator |
Takahashi Katsu 京都大学, 医学(系)研究科(研究院), 准教授 (90314202)
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Co-Investigator(Kenkyū-buntansha) |
BESSHO Kazuhisa 京都大学, 大学院医学研究科, 教授 (90229138)
SHIMIZU Akira 京都大学, 大学院医学研究科, 教授 (00162694)
SUGAI MANABU 福井大学, 大学院医学研究科, 教授 (90303891)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 歯の再生 / 歯数制御 / 分子標的治療 / USAG-1 / Runx2 / CEBP/β / 過剰歯 / 先天性無歯症 / BMP-7 / C/EBPβ / BMP7 / ゼラチンスポンジ |
Outline of Final Research Achievements |
Human teeth are diphyodont excepting the permanent molars. The number of teeth is usually strictly determined. A number of mouse mutants provide insights into the supernumerary tooth formation. The rescue of tooth formation in genetically defined mouse models clearly demonstrates the feasibility of inducing de novo tooth formation via the in situ repression of a single targeted gene. Our investigations and related studies clearly validate the hypothesis that the de novo repression of target genes could be used to stimulate arrested tooth germs in order to induce new tooth formation in mammals. Molecular targeted therapy is a type of treatment in which drugs or other substances are used to specifically attack certain cell types by interfering with critical target molecules. Molecularly targeted therapy seems to be a suitable approach in tooth regeneration.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Application of anti-BMP antibodies to immunohistochemical examination of fibrous dysplasia2015
Author(s)
Kiso, H., Takahashi, K., Kang, Y., Sakata-Goto, T., Huang, B., Tsukamoto, H. Nakashima, Y. and Bessho, K
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Journal Title
J Oral Maxillofac Surg Med Path,
Volume: 27
Pages: 106-111
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Mitochondrial function provides instructive signals for activation-induced B cell fates2015
Author(s)
Kyoung-Jin Jang, Hiroto Mano, Koji Aoki, Tatsunari Hayashi, Yukiko Nambu, Eri Hara, Katsu Takahashi, Katsuhiko Itoh, Shigeru Taketani, Kazuhiko Igarashi, Akira Shimizu and Manabu Sugai
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Journal Title
Nature Commun
Volume: 6
Issue: 1
Pages: 6750-6750
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Interactions between BMP-7 and USAG-1 (Uterine Sensitization-Associated Gene-1) Regulate Supernumerary Organ Formations2014
Author(s)
Honoka Kiso, Katsu Takahashi , Kazuyuki Saito, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang, Manabu Sugai, Akira Shimizu, Yasuhiko Tabata, Aris N. Economides, Harold C. Slavkin, Kazuhisa Bessho
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Journal Title
PlosOne
Volume: 9
Issue: 5
Pages: 96938-96944
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prospective signs of cleidocranial dysplasia in Cebpb deficiency2014
Author(s)
Boyen Huang1,2, Katsu Takahashi2*, Ernest A Jennings1 , Pongthorn Pumtang-on3 , Honoka Kiso2 , Yumiko Togo2 , Kazuyuki Saito2 , Manabu Sugai4 , Shizuo Akira5 , Akira Shimizu4 and Kazuhisa Bessho2
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Journal Title
Journal of Biomedical Science
Volume: 21
Issue: 1
Pages: 44-48
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The effect of nicotine on osteoinduction by recombinant human bone morphogenetic protein-2.2014
Author(s)
Tamura, K., Togo, Y., Kaihara, S., Hussain, A., Takahashi, K., and Bessho, K.
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Journal Title
Int J Oral Maxillofac Surg
Volume: 43
Issue: 8
Pages: 1022-1029
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] An association between anti-nuclear antibodies and HLA class II locus and heterogeneous characteristics of staining patterns: The Nagahama Study.2014
Author(s)
Terao C, Ohmura K, Yamada R, Kawaguchi T, Shimizu M, Tabara Y, Takahashi M, Setoh K, Nakayama T, Kosugi S, Sekine A, Matsuda F, Tsuneyo Mimori T on behalf of the Nagahama Study Group.
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Journal Title
Arthritis Rheumatol.
Volume: 66
Issue: 3_suppl
Pages: 3395-403
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Phenotypes of CCAAT/enhancer-binding protein beta deficiency: Hyperdontia and elongated coronoid process.2013
Author(s)
Huang, B., Takahashi, K., Sakata-Goto, T., Kiso, H., Togo, Y., Saito, K., Tsukamoto, H., Sugai, M., Akira, S., Shimizu, A. and Bessho, K.
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Journal Title
Oral Diseases
Volume: 19
Issue: 2
Pages: 144-150
DOI
Related Report
Peer Reviewed
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[Journal Article] Mastication and risk for diabetes in a Japanese population: a cross-sectional study.2013
Author(s)
Yamazaki T, Yamori M, Asai K, Nakano-Araki I, Yamaguchi A, Takahashi K, Sekine A, Matsuda F, Kosugi S, Nakayama T, Inagaki N, Bessho K; Nagahama Study Collaboration Group.
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Journal Title
PLoS One.
Volume: 8
Issue: 6
Pages: e64113-e64113
DOI
Related Report
Peer Reviewed
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[Journal Article] Assessing anteroposterior basal bone discrepancy with the Dental Aesthetic Index2013
Author(s)
Huang B, Takahashi K, Yamazaki, T., Saito, K., Yamori, M.,Asai, K., Yoshikawa Y., Kamioka H.,, Yamashiro T., Bessho K
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Journal Title
Angle Orthod
Volume: 83
Issue: 3
Pages: 527-532
DOI
Related Report
Peer Reviewed
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[Book] Feasibility of Molecularly targeted therapy for tooth regeneration: New Trends in Tissue Engineering and Regenerative Medicine- Official Book of the Japanese Society of Regenerative Medicine2015
Author(s)
3.Takahashi, K., Kiso, H., Saito, K., Togo, Y., Tsukamoto, H., Huang, B. and Bessho, K.
Total Pages
11
Publisher
In Tech
Related Report
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[Book] Gene Therapy-Tools and Potential Applications2013
Author(s)
2. Takahashi, K., Kiso, H., Saito, K., Togo, Y., Tsukamoto, H., Huang, B. and Bessho, K.
Total Pages
744
Publisher
In Tech
Related Report
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