Tongue muscle reconstruction using human mesenchymal stem cells
| Project/Area Number |
25463091
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Masaaki 佐賀大学, 医学部歯科口腔外科学講座, 教授 (10145211)
NOGUCHI Nobuhiro 佐賀県立病院好生館, 歯科口腔外科, その他 (40284658)
SHIMOHIRA Daiji 佐賀大学, 医学部歯科口腔外科学講座, 助教 (70594844)
DANJO Atsushi 佐賀大学, 医学部歯科口腔外科学講座, 講師 (80452712)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 間葉系幹細胞 / 筋組織 / 舌癌 / 温度感受性細胞シート / ナノスキャホールド |
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| Outline of Final Research Achievements |
We performed a study to regenerate muscular tissue using human mesenchymal stem cells for patients defective by treatment of tongue cancer. It was proved by animal experiments that these cells could be induced differentiation to myoblastic cells under a special environment. The clinical possibility was suggested in the future. However the ration of differentiated cells was not efficient. Improvement method is necessary. We also tried the animal experiments with layered cell sheets to use for the loss of tongue. But, our cell sheet did not really engraft on mouse tongue, since a tongue was a high flexible part. Development of portable cell sheet is necessary near the future.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia2015
Author(s)
Aijima R, Wang B, Takao T, Mihara H, Kashio M, Ohsaki Y, Zhang JQ, Mizuno A, Suzuki M, Yamashita Y, Masuko S, Goto M, Tominaga M, Kido MA
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Journal Title
FASEB J.
Volume: 29
Pages: 182-192
Related Report
Peer Reviewed
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