Elucidation of the neuropathic pain control mechanism in the ovariectomized rats

Research Project

Project/Area Number	25463134
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Surgical dentistry
Research Institution	Osaka University
Principal Investigator	SUGIMURA MITSUTAKA 大阪大学, 歯学研究科(研究院), 准教授 (90244954)
Co-Investigator(Kenkyū-buntansha)	Niwa Hitoshi 大阪大学, 大学院・歯学研究科, 教授 (30218250)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	卵巣摘出ラット / 神経障害性疼痛 / 侵害受容性疼痛 / TRPV1 / ANO1 / エストロゲン / ＴＲＰＶ1 / Ａｎｏ1 / ｃ-Ｆｏｓ / β-Estradiol / 卵巣摘出 / 三叉神経 / c-Fos / ラット / カプサイシン / 更年期
Outline of Final Research Achievements	We investigated the effect of estorogen to the neuropathic pain in the ovariectomized rats. It was revealed by the behavioral approach that estrogen acts as aggravating factors in the acute inflammatory phase of neuropathic pain and as the attenuation factor in the chronic phase. In this study, we particularly focused on the effects of estrogen in the acute inflammatory phase. Specifically, we investigated the effect of estrogen on TRPV1 and ANO1 expression level which play an important role in inflammatory pain. As a result, it has been suggested that estrogen exacerbates the inflammatory pain by enhancing the expression of TRPV1 and ANO1.