Elucidation of scar contracture molecule mechanism after cleft palate and development for development of new wound dressing

• Project/Area Number: 25463139
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kagoshima University
• Principal Investigator: KIBE TOSHIRO 鹿児島大学, 医歯学域附属病院, 助教 (50635480)
• Co-Investigator(Kenkyū-buntansha): 岸田 昭世 鹿児島大学, 医歯学域医学系, 教授 (50274064) ; 中村 典史 鹿児島大学, 医歯学域歯学系, 教授 (60217875) ; 田口 哲志 国立研究開発法人物質・材料研究機構, バイオ機能分野, MANA研究者 (70354264)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 創傷治癒 / 瘢痕拘縮 / 筋線維芽細胞 / 口唇口蓋裂 / 被覆材 / αーSMA

Outline of Final Research Achievements

The healing process of multiple wound dressings was analyzed using rat experiments in order to prevent deformation and developmental disorder of facial features caused by scar contraction of the wound. NEOVEIL restrained the initial scarring contraction and suppressed the expression of αSMA positive cells, the cause of scar contraction. As a result of this study, NEOVEIL showed the possibility of preventing scar contraction, but the epithelium was recessed without renewing on the surface layer of NEOVEIL. It seems necessary to solve these problems for new materials aimed at suppressing scar contraction.

Research Products

• [Journal Article] Examination of the early wound healing process under different wound dressing conditions, (2017)
  • Author(s): T. Kibe, T. Koga, K. Nishihara, T. Fuchigami, T. Yoshimura, K. T. Taguchi, N. Nakamura
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol. Volume: 123 Pages: 310-319
  • Peer Reviewed / Open Access
• [Presentation] 人工創傷被覆材の違いにおける上皮欠損部の治癒過程の検討 (2014)
  • Author(s): 岐部俊郎 大山健太郎 渕上貴央 吉村卓也 松永和秀 田口哲志 西原一秀 中村典史
  • Organizer: ２０１４年 第59回日本口腔外科学会総会・学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2014-10-17 – 2014-10-19
• [Presentation] Examination of the process underlying healing of epithelial defects by using different wound dressings (2014)
  • Author(s): T. Kibe, K. Oyama, T. Fuchigami, T. Yoshimura, K. Matsunaga, K. Nishihara, T. Taguchi, N. Nakamura
  • Organizer: the 2014 AAOMS(The American Association of Oral and Maxillofacial Surgeons) Annual Meeting in Honolulu
  • Place of Presentation: Honolulu
  • Year and Date: 2014-09-12
• [Presentation] Examination of the process underlying healing of epithelial defects by using different wound dressings (2014)
  • Author(s): Toshiro Kibe
  • Organizer: American Association of Oral and Maxillofacial Surgeons’ Committee
  • Place of Presentation: Honolulu, USA
• [Remarks] 鹿児島大学歯学部 研究トピックス
  • URL: http://www.hal.kagoshima-u.ac.jp/kenkyu/topics20150118.html
• [Remarks] 鹿児島大学産官学連携研究シーズ
  • URL: http://www.rdc.kagoshima-u.ac.jp/rdc/search/upload/nakamura-kibe-med.pdf