| Project/Area Number |
25463171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YONEMITSU Ikuo 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (00431940)
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| Co-Investigator(Kenkyū-buntansha) |
細道 純 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (00420258)
武居 真希 東京医科歯科大学, 歯学部, 非常勤講師 (50547445)
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| Research Collaborator |
KANAGUCHI Akemi
TAKEI Maki
IKEDA Yuhei
MIYAZAKI Mutsumi
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 顎関節 / 変形性関節症 / LIPUS / 下顎頭軟骨 / 再生 / 変形性顎関節症 / 軟骨再生 / 下顎頭 |
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| Outline of Final Research Achievements |
This study evaluated LIPUS effects in a rat TMJ-OA model. OA-like lesions were induced in the TMJ with low-dose MIA injections. Twenty-four 12-week-old male Wistar rats were divided into 4 groups: control, injected with contrast media at 12 weeks and observed to 20 weeks; LIPUS, injected with contrast media at 12 weeks and LIPUS performed from 16 to 20 weeks; MIA, injected with MIA at 12 weeks and observed to 20 weeks; and MIA+LIPUS, injected with MIA at 12 weeks and LIPUS performed from 16 to 20 weeks. BMD, BMC and BV were evaluated weekly with micro-CT. At 20 weeks of age, MIA+LIPUS group had significantly higher values than the MIA group did. The comparison of weekly results showed the MIA+LIPUS group showed a significant increase in BMD, BMC, and BV from 16 to 18 weeks.
LIPUS had significant therapeutic potential for treating TMJ-OA lesions in a 2-week period and it has non-invasive effects on the healthy mandibular condyle.
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