Development of the new molecular target therapy for phenytoin-induced gingival overgrowth using the antagonist of TRPA1 channel
| Project/Area Number |
25463180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Fumihiro 徳島大学, 病院, 講師 (70229566)
KITAMURA Takamasa 徳島大学, 大学院医歯薬学研究部, 助教 (50614020)
YAMAMOTO Aimi 徳島大学, 病院, 医員 (10630171)
UEDA Kimiko 徳島大学, 病院, 助教 (40335807)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 歯肉増殖症 / フェニトイン / p-HPPH / TRPA1 / メンソール / カンファ― / シネオール / ｐ－HPPH / カンファ―， / P-HPPH |
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| Outline of Final Research Achievements |
For a purpose to determine a disease developing mechanism of gingival hyperplasia with the phenytoin, we examined the effect that metabolites (p-HPPH) of the phenytoin gave to human normal gingiva fibroblasts (HGF). As a result, p-HPPH was suggested to restrain the expression of collagen degrading enzyme (MMP-1) in HGF.
Then, we examined whether the inhibitor of the TRPA1 channel (HC030031) interfered restraint of the MMP-1 expression by p-HPPH to develop a therapeutic drug of gingival hyperplasia. As a result, the expression of mRNA of MMP-1 which decreased by administration of p-HPPH increased by the dosage of HC030031. As a result, we found that all materials have the effects similar to HC030031. Effect of Menthol was found to be the strongest in the three.
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Report
(4 results)
Research Products
(1 results)
