Study of periodontal ligament tissue function about maintaining homeostasis and regeneration in periodontal tissues, and development of new regeneration therapy in periodontal tissues.
| Project/Area Number |
25463182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Yoshitaka 北海道大学, 歯学研究科(研究院), 准教授 (30230816)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | SDF-1 / 乳歯 / 歯根膜 / FGF-2 / 歯根膜細胞 / 間葉系幹細胞 / 恒常性 / 歯髄 |
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| Outline of Final Research Achievements |
SDF1 plays an important role in tissue regeneration, repair and homeostasis by attracting mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs). While periodontal tissues are exposed to occlusal force, injury and orthodontic force, it is unknown whether periodontal ligament(PDL) could express SDF1. Therefore, in this study, we analyzed whether PDL cells could express SDF1.
SDF1 was produced by PDL cells. SDF1 in conditioned media could induce migration of MSCs. Moreover, treatment with FGF2 suppressed SDF1 mRNA. In conclusion, we demonstrate that PDL cells may be important for maintaining the homeostasis of PDL tissue by controlling the migration of postnatal stem cells, e.g., MSCs and EPCs, to the required sites via SDF1. Several other cytokines like FGF2 may be crucial for SDF1 expression and thus also for cell-based tissue regeneration. These findings may facilitate our understanding of the mechanisms of homeostasis in the PDL tissues via SDF1 expression.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Recruitment of mesenchymal stem cells by stromal cell-derived factor 1α in pulp cells from deciduous teeth2015
Author(s)
Akazawa Y., Hasegawa T., Yoshimura Y., Chosa N., Asakawa T., Ueda K., Sugimoto A., Kitamura T., Nakagawa H., Ishisaki A., Iwamoto T.
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Journal Title
International Journal of Molecular Medicine
Volume: 36
Issue: 2
Pages: 442-448
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Recruitment of mesenchymal stem cells by stromal cell-derived factor 1α in pulp cells from deciduous teeth2015
Author(s)
Yuki Akazawa, Tomokazu Hasegawa, Yoshitaka Yoshimura, Naoyuki Chosa, Takeyoshi Asakawa, Kimiko Ueda, Asuna Sugimoto, Takamasa Kitamura, Hiroshi Nakagawa, Akira Ishisaki, and Tsutomu Iwamoto
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Journal Title
Int J Mol Med 2015年4月2日accepted
Volume: 印刷中
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells.2014
Author(s)
Aomatsu, E., Takahashi, N., Sawada, S., Okubo, N., Hasegawa, T., Taira, M., Miura, H., Ishisaki, A., and Chosa, N.
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Journal Title
Sci. Rep.
Volume: 4
Issue: 1
Pages: 3652-3652
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Establishing and SDF-1α regulation of expression on periodontal ligament cells derived from human teeth.2016
Author(s)
Takeyoshi Asakawa, Yoichi Miyamoto, Kentaro Yoshimura, Sasa Kiyoto, Tomokazu Hasegawa, Naoyuki Chosa, Akira Ishizaki, Miki Kadena, Yoko Manome, Miku Kuritani, Ryutaro Kamijo, Takahiro Funatsu
Organizer
10th Biennial conference of the pediatric dentistry association of asia
Place of Presentation
Tokyo Dome Hotel (Bunkyou-ku, Tokyo, Japan)
Year and Date
2016-05-26
Related Report
Int'l Joint Research
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[Presentation] Molecular mechanisms of SDF-1α suppression by FGF2 in dental pulp cells.2016
Author(s)
Yuki Akazawa, Tomokazu Hasegawa, Yoshitaka Yoshimura, Naoyuki Chosa, Takeyoshi Asakawa, Asuna Sugimoto, Takamasa Kitamura, Kimiko Ueda, Keita Kawarabayashi Akira Ishisaki, Riku Takahashi, Yuto Suehiro, Tsutomu Iwamoto:
Organizer
10th Biennial conference of the pediatric dentistry association of asia
Place of Presentation
Tokyo Dome Hotel (Bunkyou-ku, Tokyo, Japan)
Year and Date
2016-05-26
Related Report
Int'l Joint Research
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[Presentation] ヒト乳歯歯髄細胞の細胞株樹立2013
Author(s)
赤澤友基, 帖佐直行, 吉村善隆, 北村尚正, 藤原百合, 浅川剛吉, 石崎 明, 長谷川智一
Organizer
第51回小児歯科学会大会
Place of Presentation
長良川国際会議場（岐阜県岐阜市）
Related Report
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