Study on the surface modification of the orthodontic material using bioactive glass

• Project/Area Number: 25463195
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: IIJIMA MASAHIRO 北海道医療大学, 歯学部, 准教授 (20305915)
• Co-Investigator(Kenkyū-buntansha): HASHIMOTO MASANORI 大阪大学, 歯学研究科, 准教授 (00337164) ; MUGURUMA TAKESHI 北海道医療大学, 歯学部, 講師 (20343436)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: バイオアクティブガラス / 再石灰化 / エナメル質脱灰抑制 / 表面改質 / スパッタリング / 矯正材料 / 脱灰抑制 / エナメル質 / セラミックス

Outline of Final Research Achievements

Bioactive glass (BG) was deposited on the orthodontic alumina by radio-frequency magnetron sputtering to study the enamel remineralization. BG-coated specimens were immersed in artificial saliva for 6 months. The specimens were studied with scanning electron microscope (SEM), Raman spectroscopic analysis and micro-X-ray diffraction. Human enamels were etched with phosphoric acid and then immersed with BG-coated specimen in artificial saliva. Nanoindentation testing of the specimens was conducted during the immersion. SEM photomicrographs showed the formation of needle-like and tabular structures after immersion. Raman and micro-XRD spectra confirmed that they consisted of calcium phosphate. The mechanical properties of the etched enamel specimens immersed with BG-coated specimen recovered significantly compared to those with the non-coated specimens. BG-coated alumina can accelerate the remineralization of etched enamel.

Research Products

• [Journal Article] Inhibition of enamel demineralization and bond strength properties of bioactive glass containing 4-META/MMA-TBB-based resin adhesive (2015)
  • Author(s): Naohisa Kohda, Masahiro Iijima, Kyotaro Kawaguchi, Hirokazu Toshima, Takeshi Muguruma, Kazuhiko Endo, Itaru Mizoguchi
  • Journal Title: European Journal of Oral Sciences Volume: 123 Pages: 202-207
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Bioactive glass coating of orthodontic material for the recovery of mechanical properties of etched enamel. (2014)
  • Author(s): Iijima M, Hashimoto M, Nakagaki S, Muguruma T, Kohda N, Endo K, Mizoguchi I
  • Journal Title: Journal of Biomaterials and Tissue Engineering Volume: ４（４） Issue: 4 Pages: 1-7
  • DOI: 10.1166/jbt.2014.1171
  • Peer Reviewed / Open Access
• [Journal Article] Crystal growth on bioactive glass sputter-coated alumina in artificial saliva (2013)
  • Author(s): MASAHIRO IIJIMA, MASANORI HASHIMOTO, NAOHISA KOHDA, SUSUMU NAKAGAKI, TAKESHI MUGURUMA, KAZUHIKO ENDO, ITARU MIZOGUCHI
  • Journal Title: Dental Materials Journal Volume: 32 Pages: 775-780
  • NAID: 10031191713
  • Peer Reviewed
• [Presentation] Synthesis of novel bioactive glass compositions incorporating therapeutic zinc ions (2016)
  • Author(s): Ian Villamagna, Masahiro Iijima, John Mitchell
  • Organizer: 45th Annual Meeting of the American Association Dental Research
  • Place of Presentation: Los Angeles
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] バイオアクティブガラスにより表面改質した矯正用材料の脱灰エナメル質再石灰化能 (2014)
  • Author(s): 飯嶋雅弘、橋本正則、中垣 晋、河口馨太朗、甲田尚央、六車武史、遠藤一彦、溝口 到
  • Organizer: 第73回日本矯正歯科学会大会
  • Place of Presentation: 千葉県幕張メッセ
  • Year and Date: 2014-10-22
• [Presentation] バイオアクティブガラス含有4-META/MMA-TBBレジン系接着材料のエナメル質脱灰抑制と接着特性 (2014)
  • Author(s): 甲田尚央、飯嶋雅弘、河口馨太朗、六車武史、溝口 到
  • Organizer: 第73回日本矯正歯科学会大会
  • Place of Presentation: 千葉県幕張メッセ
  • Year and Date: 2014-10-22
• [Presentation] バイオアクティブガラスにより表面改質したブラケット用材料の結晶形成能
  • Author(s): 飯嶋 雅弘、橋本 正則、中垣 晋、甲田 尚央、六車 武史、遠藤 一彦、溝口 到
  • Organizer: 日本矯正歯科学会大会
  • Place of Presentation: 長野県松本文化会館