Novel periodontal therapy using nanocarbon coating procedure
Project/Area Number |
25463210
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Periodontology
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Research Institution | Hokkaido University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TANAKA SAORI 北海道大学, 北海道大学病院, 講師 (90344522)
KATO AKIHITO 北海道大学, 歯学研究科(研究院), 助教 (40507571)
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Co-Investigator(Renkei-kenkyūsha) |
FUGETSU BUNSHI 東京大学, 政策ビジョン研究センター, 特任教授 (40281844)
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Research Collaborator |
NISHIDA ERIKA 北海道大学, 北海道大学病院, 医員
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | ナノカーボン / カーボンナノチューブ / 酸化グラフェン / バイオマテリアル / 骨再生 / 歯周組織再生 / 抗菌性 / スキャフォールド / マクロファージ / 歯周病 / 歯根膜 / 象牙質 / 生体親和性 / イングロース / 再生 / 還元型酸化グラフェン / 細胞培養 / タンパク吸着 |
Outline of Final Research Achievements |
Biocompatibility tests were performed to evaluate the biological properties of nanocarbon materials, such as graphene oxide (GO) and carbon nanotube (CNT). In addition, tooth coating procedure using GO and regenerative scaffold including GO were developed for application to periodontal therapy. Low dose of GO and CNT consistently exhibited good biocompatibility, in particular, CNT stimulated cell proliferative activity. The tooth coating procedure using GO solution provided the antimicrobial effect to the tooth surface. GO scaffold exhibited cytocompatibility and promoted tissue healing and bone formation when implanted in tooth extraction socket or furcation periodontal defect in dog. Consequently, nanocarbon materials would be available for medical application in periodontal therapy.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] Periodontal tissue engineering by nano beta-tricalcium phosphate scaffold and fibroblast growth factor-2 in one-wall infrabony defects of dogs2016
Author(s)
K Ogawa, H Miyaji, A Kato, Y Kosen, T Momose, T Yoshida, E Nishida, S Miyata, S Murakami, H Takita, B Fugetsu, T Sugaya, M Kawanami
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Journal Title
J Periodont Res
Volume: 51
Issue: 6
Pages: 758-767
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Biological response to nanostructure of carbon nanotube/titanium composite surfaces2015
Author(s)
E Nishida, H Miyaji, J Umeda, K Kondoh, H Takita, I Kanayama, S Tanaka, A Kato, B Fugetsu, T Akasaka, M Kawanami
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Journal Title
Nano Biomedicine
Volume: 7
Pages: 11-20
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Bone augmentation using a highly porous PLGA/β-TCP scaffold containing fibroblast growth factor-2.2015
Author(s)
T Yoshida, H Miyaji, K Otani, K Inoue, K Nakane, H Nishimura, A Ibara, A Shimada, K Ogawa, E Nishida, T Sugaya, L Sun, B Fugetsu, M Kawanami.
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Journal Title
J Periodont Res
Volume: 50
Issue: 2
Pages: 265-273
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Combination of Root Surface Modification with BMP-2 and Collagen Hydrogel Scaffold Implantation for Periodontal Healing in Beagle Dogs.2015
Author(s)
A Kato, H Miyaji, R Ishizuka, K Tokunaga, K Inoue, Y Kosen, H Yokoyama, T Sugaya, S Tanaka, R Sakagami, M Kawanami.
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Journal Title
Open Dent J
Volume: 9
Issue: 1
Pages: 52-59
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparative study of bioactivity of collagen scaffolds coated with graphene oxide and reduced graphene oxide.2014
Author(s)
I Kanayama, H Miyaji, H Takita, E Nishida, M Tsuji, B Fugetsu, L Sun, K Inoue, A Ibara, T Akasaka, T Sugaya, M Kawanami.
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Journal Title
Int J Nanomedicine
Volume: 9
Pages: 3363-3373
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 金クラスターとLED光照射器による光殺菌歯科治療法の開発2015
Author(s)
宮田さほり, 宮治裕史, 西田絵利香, 川崎英也, 山本真希, 滝田裕子, 牛島夏未, 岩永俊彦, 赤坂 司, 田中佐織, 川浪雅光
Organizer
第37回日本バイオマテリアル学会大会
Place of Presentation
京都テルサ(京都府京都市)
Year and Date
2015-11-09
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[Presentation] Biocompatibility of CNT-Ti composite surface with different nanomorphologies.2015
Author(s)
E Nishida, H Miyaji, J Umeda, K Kondoh, H Takita, B Fugetsu, S Tanaka, A Kato, T Akasaka, M Kawanami.
Organizer
93rd General Session of the IADR
Place of Presentation
Hynes Convention Center (Boston, USA)
Year and Date
2015-03-11 – 2015-03-14
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[Book] Advances in Oral Tissue Engineering.2014
Author(s)
H Miyaji, M Kawanami, KW Kim, M Murata, J Kusukawa, N Okubo, A Ishisaki, Y Haikel, H Lesot, JV Ruch, H Tsujigiwa, M Arisue, N Nagai, F Nagano-Takebe, D Selimovic, K Endo, K Ito, T Arakawa, K Kusano, J Tazaki, MA Kabir, T Takuma, M Fujita, O Uehara, H Miyakawa, S Naito, F Nakazawa, J Hino, Y Minamida, I Asahina他
Total Pages
84
Publisher
Quintessence Publishing Co, Inc.
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