Development a new regenerative therapy and analysis of tissue regeneration / wound healing system by periodontal tissue stem cells
| Project/Area Number |
25463226
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯周組織再生 / 間葉系幹細胞 / 神経堤細胞 / iPS細胞 / 歯周組織幹細胞 |
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| Outline of Final Research Achievements |
（1）For the purpose of actual treatment, We have become possible to use human therapeutic iPS cells .
（2）In the future, We suppose the use of human therapeutic iPS cells . In practical application, it is very important problem to use the conventional culture system. Because these system use fetal bovine serum and non human feeder cell to culture of human iPS cells. To overcome these problems, we established non serum / non feeder culture system of human therapeutic iPS cells . We think these steps (feeder free / xeno free culture system)are very notable in this study.
（3）We succeeded inducing neural crest like cells from human iPS cells. Neural crest is developmental origin of periodontal tissue.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.2016
Author(s)
Ogawa Y, Morikawa S, Okano H, Mabuchi Y, Suzuki S, Yaguchi T, Sato Y, Mukai S, Yaguchi S, Inaba T, Okamoto S, Kawakami Y, Tsubota K, Matsuzaki Y, Shimmura S.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] CD34 and CD49f double-positive and lineage marker-negative cells isolated from human myometrium exhibit stem cell-like properties involved in pregnancy-induced uterine remodeling.2015
Author(s)
Ono M, Kajitani T, Uchida H, Arase T, Oda H, Uchida S, Ota K, Nagashima T, Masuda H, Miyazaki K, Asada H, Hida N, Mabuchi Y, Morikawa S, Ito M, Bulun SE, Okano H, Matsuzaki Y, Yoshimura Y, Maruyama T
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Journal Title
Biol Reprod
Volume: 93巻
Issue: 2
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Purified Human Dental Pulp Stem Cells Promote Osteogenic Regeneration.2015
Author(s)
Yasui T, Mabuchi Y, Toriumi H, Ebine T, Niibe K, Houlihan DD, Morikawa S, Onizawa K, Kawana H, Akazawa C, Suzuki N, Nakagawa T, Okano H, Matsuzaki Y.
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Journal Title
journal of Dental Research
Volume: 95
Issue: 2
Pages: 206-214
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Homeodomain transcription factor meis1 is a critical regulator of adult bone marrow hematopoiesis.2014
Author(s)
Ariki R, Morikawa S, Mabuchi Y, Suzuki S, Nakatake M, Yoshioka K, Hidano S, Nakauchi H, Matsuzaki Y, Nakamura T, Goitsuka R.
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Journal Title
PLoS One.
Volume: 9
Issue: 2
Pages: 87646-87646
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 糖尿病患者における歯周病原性細菌の血清抗体価に関する調査
Author(s)
飯島佑斗, 太田淳也, 深谷千絵, 笠井俊輔, 大石匠, 赤松真也子, 森川暁, 田小森純子, 江口徹, 税所芳史, 河合俊英, 伊藤裕, 中川種昭
Organizer
第56回秋季日本歯周病学会学術大会
Place of Presentation
前橋市民文化会館（群馬県）
Related Report
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