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Development a new regenerative therapy and analysis of tissue regeneration / wound healing system by periodontal tissue stem cells

Research Project

Project/Area Number 25463226
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontology
Research InstitutionKeio University

Principal Investigator

Morikawa Satoru  慶應義塾大学, 医学部, 助教 (00424169)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords歯周組織再生 / 間葉系幹細胞 / 神経堤細胞 / iPS細胞 / 歯周組織幹細胞
Outline of Final Research Achievements

(1)For the purpose of actual treatment, We have become possible to use human therapeutic iPS cells .
(2)In the future, We suppose the use of human therapeutic iPS cells . In practical application, it is very important problem to use the conventional culture system. Because these system use fetal bovine serum and non human feeder cell to culture of human iPS cells. To overcome these problems, we established non serum / non feeder culture system of human therapeutic iPS cells . We think these steps (feeder free / xeno free culture system)are very notable in this study.
(3)We succeeded inducing neural crest like cells from human iPS cells. Neural crest is developmental origin of periodontal tissue.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (28 results)

All 2016 2015 2014 2013 Other

All Journal Article (9 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (16 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Applications of Mesenchymal Stem Cells and Neural Crest Cells in Craniofacial Skeletal Research.2016

    • Author(s)
      Morikawa S, Ouchi T, Shibata S, Fujimura T, Kawana H, Okano H, Nakagawa T.
    • Journal Title

      Stem Cells International

      Volume: 2849879 Issue: 1 Pages: 1-8

    • DOI

      10.1155/2016/2849879

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.2016

    • Author(s)
      Ogawa Y, Morikawa S, Okano H, Mabuchi Y, Suzuki S, Yaguchi T, Sato Y, Mukai S, Yaguchi S, Inaba T, Okamoto S, Kawakami Y, Tsubota K, Matsuzaki Y, Shimmura S.
    • Journal Title

      eLife

      Volume: 5

    • DOI

      10.7554/elife.09394

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CD34 and CD49f double-positive and lineage marker-negative cells isolated from human myometrium exhibit stem cell-like properties involved in pregnancy-induced uterine remodeling.2015

    • Author(s)
      Ono M, Kajitani T, Uchida H, Arase T, Oda H, Uchida S, Ota K, Nagashima T, Masuda H, Miyazaki K, Asada H, Hida N, Mabuchi Y, Morikawa S, Ito M, Bulun SE, Okano H, Matsuzaki Y, Yoshimura Y, Maruyama T
    • Journal Title

      Biol Reprod

      Volume: 93巻 Issue: 2 Pages: 1-9

    • DOI

      10.1095/biolreprod.114.127126

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Purified Human Dental Pulp Stem Cells Promote Osteogenic Regeneration.2015

    • Author(s)
      Yasui T, Mabuchi Y, Toriumi H, Ebine T, Niibe K, Houlihan DD, Morikawa S, Onizawa K, Kawana H, Akazawa C, Suzuki N, Nakagawa T, Okano H, Matsuzaki Y.
    • Journal Title

      journal of Dental Research

      Volume: 95 Issue: 2 Pages: 206-214

    • DOI

      10.1177/0022034515610748

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 幹細胞を用いた新規口腔組織再生療法の確立2015

    • Author(s)
      森川暁
    • Journal Title

      Journal of Bio-Integration

      Volume: 5 Pages: 9-12

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 糖尿病患者における歯周病原細菌の血清抗体価に関する調査2014

    • Author(s)
      太田淳也,深谷千絵,笠井俊輔,赤松真也子,森川暁,田小森純子,江口徹,税所芳史,河合俊英,伊藤裕,中川種昭
    • Journal Title

      日本歯周病学会会誌

      Volume: 56(4) Pages: 414-422

    • NAID

      130004842587

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Homeodomain transcription factor meis1 is a critical regulator of adult bone marrow hematopoiesis.2014

    • Author(s)
      Ariki R, Morikawa S, Mabuchi Y, Suzuki S, Nakatake M, Yoshioka K, Hidano S, Nakauchi H, Matsuzaki Y, Nakamura T, Goitsuka R.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 2 Pages: 87646-87646

    • DOI

      10.1371/journal.pone.0087646

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] LNGFR+ Thy-1+ Vcam-1hi+ cells reveal functionally distinct subpopulations in mesenchymal stem cells.2013

    • Author(s)
      Mabuchi Y Morikawa S, Harada S; Niibe K, Suzuki S, Renault-Mihara F, Houlihan DD, Akazawa C, Okano H, *Matsuzaki Y.
    • Journal Title

      Stem Cell Reports

      Volume: 1(2) Issue: 2 Pages: 152-165

    • DOI

      10.1016/j.stemcr.2013.06.001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 顎下部に生じた孤立性線維性腫瘍の1例2013

    • Author(s)
      杉山 健太郎, 森川 暁, 山田 学, 岩渕 絵美, 岩渕 博史, 内山 公男
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 59 Pages: 632-636

    • NAID

      40019842074

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ヒトES/iPS細胞由来LNGFR+THY-1+神経堤様細胞は間葉系幹細胞の性質をもつ2016

    • Author(s)
      黄地健仁 森川暁 芝田晋介 奥野博庸 大山学 赤松和土 岡野栄之 中川種昭
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] A simple method to generate a large amount of developmentally selected mesenchymal stem cells2015

    • Author(s)
      Ouchi, T. Morikawa, S. Okano, H. Nakagawa, T.
    • Organizer
      第58回秋季日本歯周病学会学術大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Interaction and Invagination of Odontogenic Epithelial/Mesenchymal Cells Derived from Human iPS Cells2015

    • Author(s)
      Ouchi, T. Morikawa, S. Okano, H. Nakagawa, T.
    • Organizer
      第36回日本炎症・再生医学会
    • Place of Presentation
      虎ノ門ヒルズフォーラム(東京都港区)
    • Year and Date
      2015-07-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] A case report of severe generalized chronic periodontitis in a patient with Behcet’s disease2015

    • Author(s)
      Morikawa, S. Ouchi, T. Nakagawa, T.
    • Organizer
      EuroPerio8 (8TH CONFERENCE OF THE EUROPEAN FEDERATION OF PERIODONTLOGY)
    • Place of Presentation
      LONDON, United Kingdom, ExCel London
    • Year and Date
      2015-06-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Purified-Mesenchymal stem cells in human induced pluripotent stem cells derived from neural crest cells2015

    • Author(s)
      Ouchi, T. Morikawa, S. Nakagawa, T.
    • Organizer
      EuroPerio8 (8TH CONFERENCE OF THE EUROPEAN FEDERATION OF PERIODONTLOGY)
    • Place of Presentation
      LONDON, United Kingdom, ExCel London
    • Year and Date
      2015-06-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Generation of odontogenic cells from human induced pluripotent stem cells2015

    • Author(s)
      Ouchi, T. Morikawa, S. Okano, H. Nakagawa, T.
    • Organizer
      第58回春季日本歯周病学会学術大会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 幹細胞細胞を用いた新規口腔組織再生療法とは2015

    • Author(s)
      森川 暁
    • Organizer
      第5回バイオインテグレーション学会学術大会・総会
    • Place of Presentation
      東京
    • Year and Date
      2015-03-29
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 当科を受診したHIV感染症患者の臨床的検討2015

    • Author(s)
      矢島 祥助,加藤 伸,森川 暁,池浦 一裕,藤田 康平,佐藤 英和,角田 和之,中川種昭
    • Organizer
      第24回日本有病者歯科医療学会総会・学術大会
    • Place of Presentation
      旭川
    • Year and Date
      2015-03-20 – 2015-03-22
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒトiPS細胞由来神経堤細胞群における効率的な純化間葉系幹細胞の回収2015

    • Author(s)
      黄地 健仁,森川 暁,新部 邦透,奥野 博庸,赤松 和土,中川 種昭,岡野 栄之
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2015-03-19 – 2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Cetuximab耐性口腔扁平上皮癌に対する治療の可能性2015

    • Author(s)
      吉川桃子,莇生田整治,森川暁,臼田慎,宮下英高,河奈裕正,中川種昭,佐谷秀行,永野修
    • Organizer
      第33回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      奈良
    • Year and Date
      2015-01-29 – 2015-01-30
    • Related Report
      2014 Research-status Report
  • [Presentation] コモン・マーモセットにおける歯科口腔解剖及び疾患2015

    • Author(s)
      黄地 健仁,森川 暁,石淵 智子,植松 明子,岡原 則夫,井上貴史,岡原 純子,中川 種昭,佐々木 えりか,岡野 栄之
    • Organizer
      第4回マーモセット研究会大会
    • Place of Presentation
      犬山
    • Year and Date
      2015-01-22 – 2015-01-23
    • Related Report
      2014 Research-status Report
  • [Presentation] ベーチェット病を伴った広汎型重度慢性歯周炎患者の一症例2014

    • Author(s)
      森川 暁, 稲葉 晶子, 黄地 健仁, 中川 種昭
    • Organizer
      第57回秋季日本歯周病学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 抗精神病薬による薬剤性口顎ジストニアを生じた1例2013

    • Author(s)
      森川暁, 吉田重之, 岩崎良太郎, 河奈裕正, 中川種昭
    • Organizer
      第56回春季日本歯周病学会学術大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 間葉系幹細胞の低酸素環境下におけるNotchシグナルを介した未分化性維持機構の解明2013

    • Author(s)
      荒木大輔, 新部邦透, 森川暁, 中川種昭
    • Organizer
      第56回春季日本歯周病学会学術大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒト間葉系幹細胞の予期的分離と機能解析2013

    • Author(s)
      森川暁, 新部邦透, 馬渕洋, 松崎有未, 岡野栄之, 中川種昭
    • Organizer
      第67回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      栃木県総合文化センター(栃木県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 糖尿病患者における歯周病原性細菌の血清抗体価に関する調査

    • Author(s)
      飯島佑斗, 太田淳也, 深谷千絵, 笠井俊輔, 大石匠, 赤松真也子, 森川暁, 田小森純子, 江口徹, 税所芳史, 河合俊英, 伊藤裕, 中川種昭
    • Organizer
      第56回秋季日本歯周病学会学術大会
    • Place of Presentation
      前橋市民文化会館(群馬県)
    • Related Report
      2013 Research-status Report
  • [Book] the Quintessence 口腔外科 YEAR BOOK 一般臨床家,口腔外科医のための口腔外科ハンドマニュアル'15 口腔領域における再生医療の最前線① 口腔上皮の再生2015

    • Author(s)
      森川暁 黄地健仁 中川種昭 河奈裕正 岡野栄之
    • Total Pages
      5
    • Publisher
      クインテッセンス出版
    • Related Report
      2015 Annual Research Report
  • [Book] 実験医学別冊 最強のステップUPシリーズ 直伝!フローサイトメトリー 面白いほど使いこなせる2014

    • Author(s)
      森川暁, 松崎有未
    • Total Pages
      278
    • Publisher
      羊土社
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] ヒトiPS細胞から、ヒト歯原性上皮細胞やヒト歯原性間葉細胞を製造する方法2016

    • Inventor(s)
      黄地健仁 森川暁 中川種昭 岡野栄之
    • Industrial Property Rights Holder
      黄地健仁 森川暁 中川種昭 岡野栄之
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-073957
    • Filing Date
      2016-04-01
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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