Effects of hydrogen-rich water on aging periodontal tissues

• Project/Area Number: 25463243
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: AZUMA TETSUJI 岡山大学, 医歯(薬)学総合研究科, 助教 (80432649)
• Co-Investigator(Kenkyū-buntansha): MORITA Manabu 岡山大学, 医歯薬学総合研究科, 教授 (40157904) ; TOMOFUJI Takaaki 岡山大学, 医歯薬学総合研究科, 准教授 (80335629) ; ENDO Yasumasa 岡山大学, 病院, 医員 (50580213)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 抗加齢 / 水素水 / ラット / 歯周組織

Outline of Final Research Achievements

Oxidative stress is involved in age-related reactions. The anti-oxidative effects of hydrogen-rich water suppress oxidative stress, which may aid in inhibiting age-related reactions. We investigated the effects of drinking hydrogen-rich water on aging periodontal tissues in healthy rats. Four-month-old male rats were divided into two groups: the experimental group (hydrogen-rich water treatment) and the control group (distilled water treatment). The experimental group exhibited lower periodontal oxidative stress at 16 months of age than the control group. Although protein expression of interleukin-1b did not differ, gene expression of Nod-like receptor protein 3 inflammasomes was activated in periodontal tissues from the experimental group as compared with the control group. Drinking hydrogen-rich water is proposed to have anti-aging effects on periodontal oxidative stress, but not on inflammatory reactions in healthy rats.

Research Products

• [Journal Article] Effects of hydrogen-rich water on aging periodontal tissues in rats. (2014)
  • Author(s): Tomofuji T, Kawabata Y, Kasuyama K, Endo Y, Yoneda T, Yamane M, Azuma T, Ekuni D, Morita M.
  • Journal Title: Scientific Reports Volume: 4 Pages: 5534-5534
  • DOI: 10.1038/srep05534
  • NAID: 120005465581
  • Peer Reviewed / Open Access
• [Presentation] Effects of Obesity on Periodontal MicroRNAs Expression in Rats (2016)
  • Author(s): Tomofuji T, Kunitomo M, Irie K, Azuma T, Machida T, Yoneda T, Miyai H, Ekuni D, Morita M
  • Organizer: 94ｔｈ Annual Meeting of the International Association for Dental Research (IADR 2016)
  • Place of Presentation: Seoul
  • Year and Date: 2016-06-22
  • Int'l Joint Research