| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Radiotherapy for head and neck cancers and/or chemotherapy can cause salivary gland dysfunction and subsequent xerostomia, leading to poor quality of life (QOL) in cancer survivors. To understand the molecular mechanism of the salivary gland dysfunction and develop a preventive care, we are trying to establish an ex vivo salivary gland culture system. To develop the culture system, we tested the effects of growth factors on cultured epithelia of mouse embryonic submandibular glands. This study showed that it is possible to establish the ex vivo salivary gland culture system which can maintain c-Kit+ cells by adding NRG1 + FGF1 and differentiate into AQP5+ cells by removing FGF1 whenever necessary.
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