| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
ABC half transporters Abcg5 and Abcg8, which form heterodimer in the liver bile canaliculi, promote the secretion of cholesterol into bile. Hyperfunction of these transporters causes the formation of cholesterol gallstones in the bile. We previously demonstrated diet-induced hypernutrition caused a significant increase in the function and expression of these transporters in bile canaliculi, the mechanisms underlying this phenomenon remained to be clarified. In this study, we investigated how hypernutrition affects the canalicular trafficking and the function of Abcg5/Abcg8. As a result, we clarified that diet-induced cholesterol loading into liver accelerates the trafficking of Abcg5/Abcg8 from the intrahepatic pools to the bile canalicular membrane through cAMP signaling machinery.
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