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The basic investigation on the organ differences of fatty acid beta-oxidation system

Research Project

Project/Area Number 25504016
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrated Nutrition Science
Research InstitutionFujita Health University

Principal Investigator

USUDA Nobuteru  藤田保健衛生大学, 医学部, 教授 (30135123)

Co-Investigator(Kenkyū-buntansha) FUKASAWA Motoaki  藤田保健衛生大学, 医学部, 助教 (70387728)
MORIYAMA Yohsuke  藤田保健衛生大学, 医学部, 助教 (00452532)
ATSUZAWA Kimie  藤田保健衛生大学, 医学部, 助教 (60387727)
Co-Investigator(Renkei-kenkyūsha) HASHIMOTO Takashi  藤田保健衛生大学, 医学部, 客員教授 (80009935)
YAMAGUCHI Seiji  島根大学, 医学部, 教授 (60144044)
FUKAO Toshiyuki  岐阜大学, 医学部, 教授 (70260578)
TANAKA Masashi  地方独立行政法人東京都健康長寿医療センター, 研究所, 教授 (60155166)
SHIMOMURA Atsushi  北海道医療大学, 心理科学部, 教授 (50340237)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords栄養科学 / 脂肪酸β酸化系 / 臓器特異性
Outline of Final Research Achievements

Hyperlipidemia is one of the causes of arteriosclerosis and fatty liver, which are risk factors of ischemic heart diseases and hepatic cirrhosis. The improvement of fatty acid metabolism can prevent and treat hyperlipidemia. All kinds of fatty acid are catabolized by mitochondrial fatty acid beta-oxidation system, which play central roles in energy production, however, needs further elucidation. Its physiological significance was investigated by studying the localization and the metabolic regulation by transcription factors PPARs, by employing whole body tissues and primary cultured cells from various organs.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (26 results)

All 2016 2015 2014 2013 Other

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (16 results)

  • [Journal Article] Activation of STAT3 in endothelial cells of chronic subdural hematoma outer membranes.2016

    • Author(s)
      Osuka K, Watanabe Y, Usuda N, Aoyama M, Kawaguchi R, Watabe T, Takayasu M.
    • Journal Title

      World Neurosurgery.

      Volume: in press. Pages: 00-00

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comprehensive genomic analysis reveals the genetic landscape of mitochondrial respiratory chain deficiency.2016

    • Author(s)
      Kohda M, Mizuno Y, Hirata T, Yatsuka Y, Yamashita, Okuda A, Borna NN, Banshoya K, Ohnuma K, Suzuki T, Nagao A, Maehata H, Matsuda F, Higasa K, Nagasaki M, Yasuda J, Yamamoto M, Fushimi T, Shimura M, Kaiho-Ichimoto K, Harashima H, Yamazaki T, Mori M, Murayama K, Ohtake A, Okazaki Y.
    • Journal Title

      PLoS Genetics:

      Volume: 12(1) Issue: 1 Pages: e1005679-e1005679

    • DOI

      10.1371/journal.pgen.1005679

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Increased ICP promotes CaMKII-mediated phosphorylation of neuronal NOS at Ser⁸⁴⁷ in the hippocampus immediately after subarachnoid hemorrhage.2015

    • Author(s)
      Makino K, Osuka K, Watanabe Y, Usuda N, Hara M, Aoyama M, Takayasu M, Wakabayashi T
    • Journal Title

      Brain Res

      Volume: 1616 Pages: 19-25

    • DOI

      10.1016/j.brainres.2015.04.048

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collagen fibers induce expansion of receptive field of Pacinian corpuscles2015

    • Author(s)
      Yoshihiro Tanka, Tatsuya Ito, Masayoshi Hashimoto, Motoaki Fukasawa, Nobuteru Usuda, Akihito Sano
    • Journal Title

      Advanced Robotics

      Volume: 29 Issue: 11 Pages: 1-7

    • DOI

      10.1080/01691864.2014.1003194

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of Mitogen-Activated Protein Kinases in Chronic Subdural Hematoma Outer Membranes.2015

    • Author(s)
      Aoyama M, Osuka K, Usuda N, Watanabe Y, Kawaguchi R, Nakura T, Takayasu M
    • Journal Title

      J Neurotrauma

      Volume: 32 Issue: 14 Pages: 1064-1070

    • DOI

      10.1089/neu.2014.3594

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eotaxin-3 activates Smad through the TGF-β1 pathway in chronic subdural hematoma outer membranes.2014

    • Author(s)
      Osuka K, Watanabe Y, Usuda N, Aoyama M, Takeuchi M, Takayasu M.
    • Journal Title

      J Neurotrauma

      Volume: 31 Issue: 16 Pages: 1451-1456

    • DOI

      10.1089/neu.2013.3195

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of the JAK/STAT3/SOCS3 signaling pathway in herniated lumbar discs.2014

    • Author(s)
      Osuka K, Usuda N, Aoyama M, Yamahata H, Takeuchi M, Yasuda M, Takayasu M.
    • Journal Title

      Neurosci Lett

      Volume: 569 Pages: 55-58

    • DOI

      10.1016/j.neulet.2014.03.045

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The first case in Asia of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (HSD10 disease) with atypical presentation.2014

    • Author(s)
      Fukao T, Akiba K, Goto M, Kuwayama N, Morita M, Hori T, Aoyama Y, Venkatesan R, Wierenga R, Moriyama Y, Hashimoto T, Usuda N, Murayama K, Ohtake A, Hasegawa Y, ShigematsuY, Hasegawa Y.
    • Journal Title

      J Hum Genet

      Volume: 59 Issue: 11 Pages: 609-614

    • DOI

      10.1038/jhg.2014.79

    • NAID

      40020269650

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of neuronal nitric oxide synthase at Ser1412 in the dentate gyrus of rat brain after transient forebrain ischemia.2013

    • Author(s)
      Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Takayasu M.
    • Journal Title

      Neurochem Int.

      Volume: 63 Pages: 269-74

    • Related Report
      2013 Research-status Report
  • [Journal Article] Different modifications of phosphorylated Smad3C and Smad3L through TGF-β after spinal cord injury in mice.2013

    • Author(s)
      Joko M, Osuka K, Usuda N, Atsuzawa K, Aoyama M, Takayasu M.
    • Journal Title

      Neurosci Lett.

      Volume: 549 Pages: 168-72

    • Related Report
      2013 Research-status Report
  • [Presentation] ドパミン神経細胞の施灸刺激に対する反応性の組織化学的解析2016

    • Author(s)
      深澤元晶、須崎大地、臼田信光
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      福島県郡山市ビッグパレットふくしま
    • Year and Date
      2016-03-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 施灸に対する脳反応についての実験的研究2016

    • Author(s)
      深澤元晶
    • Organizer
      第1回 東洋医学研究についての解剖学所の集い
    • Place of Presentation
      福島県郡山市ビッグパレットふくしま
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高感度免疫組織学 CARD 法の脳科学への応用:施灸・ニコチン刺激における VTA ドパミン神経細胞の解析2015

    • Author(s)
      深澤 元晶、須崎 大地、木下 雄貴、臼田 信光
    • Organizer
      第56回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      大阪府枚方市関西医科大学
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 連続スライスSEMと組織化学的手法を用いた三次元超微構造観察技術によるペルオキシソーム分裂・増殖の解析2015

    • Author(s)
      森山陽介、深澤元晶、新美元、臼田信光
    • Organizer
      第31回医学生物学顕微鏡技術学会
    • Place of Presentation
      愛知県名古屋市名古屋市立大学
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 施灸の報酬特性に関する研究2015

    • Author(s)
      深澤元晶、木下雄貴、中井さち子、渡仲三、臼田信光
    • Organizer
      第64回全日本鍼灸学会学術大会
    • Place of Presentation
      福島県郡山市ビッグパレットふくしま
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 超高圧電子顕微鏡と連続スライスSEMによる細胞小器官の三次元超微構造解析の試み2015

    • Author(s)
      森山陽介、厚沢季美江、榎本早希子、荒井重勇、臼田信光
    • Organizer
      第71回顕微鏡学会
    • Place of Presentation
      京都府京都市京都国際会館
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 連続ブロック表面走査型電子顕微鏡(SBF-SEM)を用いた三次元超微構造観察によるペルオキシソーム分裂・増殖の解析2015

    • Author(s)
      森山陽介、臼田信光、深澤元晶、宮崎直幸、村田和義
    • Organizer
      第120回日本解剖学会全国学術集会
    • Place of Presentation
      兵庫県神戸市 神戸国際会議場
    • Year and Date
      2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] SBF-SEM Observation on Histochemically Stained Specimens­Three Dimensional Analyses of Peroxisomal Proliferations.2015

    • Author(s)
      森山陽介、宮崎直幸、村田和義、深澤元晶、臼田信光
    • Organizer
      IGER International Symposium on Frontiers in Biological Research with Advanced Electron Microscope Technologies
    • Place of Presentation
      愛知県名古屋市 名古屋大学理学部
    • Year and Date
      2015-01-15
    • Related Report
      2014 Research-status Report
  • [Presentation] ラット初代培養繊維芽細胞のIVPAによる解析とミトコンドリア脂肪酸β酸化系酵素の局在2014

    • Author(s)
      深澤元晶、臼田信光、厚沢季美江、古居みどり、橋本隆、山口清次
    • Organizer
      第12回アジア先天代謝異常症シンポジウム
    • Place of Presentation
      宮城県仙台市 東北大学医学部
    • Year and Date
      2014-11-13 – 2014-11-15
    • Related Report
      2014 Research-status Report
  • [Presentation] 初代培養Sertoli細胞の組織化学的特徴とミトコンドリア脂肪酸β酸化系酵素の免疫組織化学2014

    • Author(s)
      深澤元晶、臼田信光、厚沢季美江、古居みどり、橋本隆、山口清次
    • Organizer
      第55回組織細胞化学会全国学術集会
    • Place of Presentation
      長野県松本市 信州大学医学部
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 初代培養神経細胞および星状膠細胞のミトコンドリア脂肪酸β酸化系の免疫組織化学とIVPAによる解析2014

    • Author(s)
      臼田信光、厚沢季美江、深澤元晶、松澤綾美、古居みどり、橋本隆、山口清次
    • Organizer
      第55回組織細胞化学会全国学術集会
    • Place of Presentation
      長野県松本市 信州大学医学部
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 初代培養繊維芽細胞のミトコンドリア脂肪酸β酸化系の免疫組織化学とIVPAによる解析2014

    • Author(s)
      深澤元晶、臼田信光、厚沢季美江、古居みどり、橋本隆、山口清次
    • Organizer
      第55回組織細胞化学会全国学術集会
    • Place of Presentation
      長野県松本市 信州大学医学部
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] SBF-SEM を用いた細胞の三次元超微構造観察

    • Author(s)
      森山陽介、臼田信光、厚沢季美江、宮崎直幸、村田和義、深澤元晶
    • Organizer
      第 73 回日本解剖学会中部支部学術集会
    • Place of Presentation
      甲府
    • Related Report
      2013 Research-status Report
  • [Presentation] SBF-SEM MERLIN 3Viewを用いた細胞の三次元超微構造観察

    • Author(s)
      森山陽介、臼田信光、厚沢季美江、宮崎直幸、村田和義、深澤元晶
    • Organizer
      生理研研究会「電子顕微鏡機能イメージングの医学・生物学への応用」
    • Place of Presentation
      岡崎
    • Related Report
      2013 Research-status Report
  • [Presentation] 日本初のHSD10病(2-メチル-3-ヒドロキシブチリル-CoA脱水素酵素)欠損症の報告The first case of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (HS D10 disease) in Japan

    • Author(s)
      深尾敏幸、 秋葉和壽、桑山信希、森田実喜子、青山友佳、後藤正博、ヴェンカテサン ラジャラン、ビエレンガ リカート、臼田信光、森山陽介、重松陽介、長谷川有紀、大竹明、堀友博、長谷川行洋
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] SBF-SEMを用いたペルオキシソーム増殖の三次元超微構造観察

    • Author(s)
      森山陽介、臼田信光、厚沢季美江、宮崎直幸、村田和義、深澤元晶
    • Organizer
      第119回日本解剖学会全国学術集会
    • Place of Presentation
      下野
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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