| Project/Area Number |
25505005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Regenerative medicine
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岡 陽子 帝京大学, 医学部, 助手 (00599673)
白崎 良輔 帝京大学, 医学部, 助手 (40569133)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 皮膚線維芽細胞 / インターロイキン１ベータ / 血管内皮前駆細胞 / CD34 / CD41 / CD31 / CD45 / IL-1 beta / HSC / myofibroblast / HDF / human dermal fibroblast / hematopoietic stem cell / Interleukin-1 / VEGF-A / poly I:C / electrical stimulation / ヒト皮膚線維芽細胞 / 造血幹細胞 / 脱分化 / interleukin 1 beta / VEGF-C |
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| Outline of Final Research Achievements |
When an adult human dermal fibroblast (HDF) was cultured with interleukin (IL)-1-beta (b), vascular endothelial growth factor (VEGF)-A, erythropoietin (EPO), anti-human VEGF-C antibody (Ab) and anti-human tumor necrosis factor (TNF)-alpha (a) Ab, hematopoiesis-related genes expressed; however, culturing cells were morphologically fibroblasts (56th ASH). We also reported that hemogenic endothelium-relating molecules expressed in HDF with poly (I:C) culture and an electrical stimulation (44th ISEH).
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