Anxiety- and depression-like behaviors in GNL/SMP30 knockout mice with hereditary defect in vitamin C biosynthesize.
| Project/Area Number |
25560047
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Keio University (2015)
Ochanomizu University (2013-2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Suzuki Emiko お茶の水女子大学, 大学院人間文化創成科学研究科, 教授 (80154524)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | ビタミンＣ / 不安症 / うつ病 / 成育環境 / ストレス脆弱性 / セロトニン神経 / ビタミンC / 社会的心理ストレス / 不安様行動 / 抑うつ症状 / 不安 / 抑うつ / ストレス / 社会心理的環境 |
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| Outline of Final Research Achievements |
We studied male and female senescence marker protein-30 (SMP30)/ gluconolactonase (GNL) knockout (KO) mice, totally lacks the ability to synthesize vitamin C similar to a comparable deficit seen in humans, in several behavioral paradigms designed to evaluate anxiety and depression in terms of the impact vitamin C has on mental health. Two environments were established based on hierarchical social relations of stable or unstable housing’s susceptibility to anxiety- and depressive-like behaviors.
Vitamin C deficiency developed anxiety- and depression-like behaviors. When comparing stable vs. unstable social conditions, results showed that males have a low tolerance for novel / inescapable events, whereas females are more vulnerable to habitual / inescapable situations. We found that socially unstable subjects showed significantly lower GSH levels than the stable group.
These results revealed a fact that vitamin C is important for preventing psychiatric disorders.
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Report
(4 results)
Research Products
(8 results)
