Molecular basis of immunomodulatory effect of dietary alpha-glucans

Research Project

Project/Area Number	25560051
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Eating habits
Research Institution	Hiroshima University
Principal Investigator	KAWAMOTO Seiji 広島大学, 先端物質科学研究科, 教授 (90294537)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	α-グルカン / 米由来α-グルカン / 自然免疫賦活化
Outline of Final Research Achievements	Objective of this study was to test the hypothesis that rice-derived alpha-glucan plays a role in health-promotion of Japanese people through modulation of host-defense system. Oral feeding with rice-derived starch significantly suppressed the development of nasal symptoms in a murine model of allergic rhinitis without affecting adaptive immunity. The anti-inflammatory effect was more potent in uruchi-rice than in mochi-rice, suggesting that a major anti-allergic alpha-glucan unit was amylose. I also found a possibility that one could modulate such anti-allergic potency by regulation of rice starch consumptions.

Report

(3 results)