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High-throughput decontamination technology for autologous hematopoietic stem-cell transplantation

Research Project

Project/Area Number 25560190
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionThe University of Tokyo

Principal Investigator

GODA Keisuke  東京大学, 理学(系)研究科(研究院), 教授 (70518696)

Co-Investigator(Kenkyū-buntansha) YAMANE Daisuke  東京工業大学, 精密工学研究所, 助教 (70634096)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsフローサイトメトリー / マイクロ流体工学 / レーザー / 白血病 / 自家造血幹細胞移植 / ハイスループット / マイクロ流体 / 分析化学 / 時価造血幹細胞移植 / 造血幹細胞移植 / 白血病治療
Outline of Final Research Achievements

We developed an optofluidic system for high-throughput screening of a large heterogeneous population of cells based on their morphological and biochemical features. This system is based on an integration of an ultrafast optical imager with a multi-color fluorescence analyzer for simultaneous image- and fluorescence-based evaluation of every single cell in a large population with a high throughput of 10,000 cells/s. This system is expected to be useful for high-throughput identification and removal of cancer cells that contaminate grafts in autologous hematopoietic stem-cell transplantation. This work has been absorbed into the ImPACT program in which a far more advanced system is currently under development.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2014

All Patent(Industrial Property Rights) (1 results)

  • [Patent(Industrial Property Rights)] 特定細胞除去装置および特定細胞除去用流路並びに特定細胞除去方2014

    • Inventor(s)
      合田圭介
    • Industrial Property Rights Holder
      合田圭介
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-11-18
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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