Is bradycardia with diving reflex cardiovascular risk index?

• Project/Area Number: 25560376
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Kokushikan University
• Principal Investigator: KAWANO Hiroshi 国士舘大学, 文学部, 講師 (40508256)
• Co-Investigator(Renkei-kenkyūsha): SAKAMOTO Shizuo 早稲田大学, スポーツ科学部, 教授 (00266032) ; GANDO Yuko 独立行政法人国立健康・栄養研究所, 健康増進研究部, 研究員 (60613932) ; KONISHI Masayuki 早稲田大学, スポーツ科学部, 助教 (10711187)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 潜水反射徐脈 / 循環器系疾患リスク / 加齢 / 潜水反射 / 動脈硬化 / 潜水反射試験 / 循環器系疾患 / 副交感神経 / 徐脈 / 心肺体力

Outline of Final Research Achievements

First, we determined whether there is circadian rhythm for bradycardia with diving reflex. Our study found lower heart rate to diving reflex in morning than that in daytime and early-evening, suggesting that it is necessary to consider circadian rhythm when performing diving reflex.
Second, we determined effect of aging on bradycardia with diving reflex. The results of the present study indicated that bradycardia with diving reflex in older was lower compared with that in young men. That is, diving reflex bradycardia is affected by aging. Therefore, this suggests that diving reflex bradycardia may be cardiovascular risk index.

Research Products

• [Journal Article] Suitability of modified tandem-bicycle ergometer for the improvement of physical fitness and athletic performance (2015)
  • Author(s): Onodera S, Yoshioka A, Yamaguchi H, Matsumoto N, Nishimura K, Kawano H, Saito T, Arakane K, Hayashi S, Takagi Y, Wada T, Murata M, Seki K, Nose Y, Bick W R, Katayama K, Ogita F.
  • Journal Title: Journal of Physical Fitness and Sports Medicine Volume: 4(2)
  • NAID: 130005073628
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Higher cardiorespiratory fitness attenuates the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism (2014)
  • Author(s): Iemitsu M, Fujie S, Murakami H, Sanada K, Kawano H, Gando Y, Kawakami R, Tanaka N, Miyachi M.
  • Journal Title: European Journal Applied Physiology Volume: 114(7) Issue: 7 Pages: 1421-1428
  • DOI: 10.1007/s00421-014-2862-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Arterial wall elasticity and various physical activity (2013)
  • Author(s): Kawano H.
  • Journal Title: Kokushikan Journal of the Humanities Volume: 46 Pages: 29-51
  • NAID: 120005957601
• [Journal Article] Lack of age-related increase in carotid artery wall viscosity in cardiorespiratory fit men (2013)
  • Author(s): Hiroshi Kawano, Kenta Yamamoto, Yuko Gando, Michiya Tanimoto, Haruka Murakami, Yumi Ohmori, Kiyoshi Sanada, Izumi Tabata, Mitsuru Higuchi, Motohiko Miyachi
  • Journal Title: Journal of Hypertension Volume: 31(12) Issue: 12 Pages: 2370-2379
  • DOI: 10.1097/hjh.0b013e328364cbba
  • Peer Reviewed
• [Journal Article] Higher cardiorespiratory fitness attenuates arterial stiffening associated with the Ala54Thr polymorphism in FABP2. (2013)
  • Author(s): Fujie S, Iemitsu M, Murakami H, Sanada K, Kawano H, Gando Y, Kawakami R, Miyachi M.
  • Journal Title: Physiol Genomics Volume: 45 Issue: 6 Pages: 237-242
  • DOI: 10.1152/physiolgenomics.00089.2012
  • Peer Reviewed
• [Presentation] 日本人女性におけるエストロゲン受容体β遺伝子多型と頸動脈壁厚との関連 (2014)
  • Author(s): 林貢一郎，家光素行，村上晴香，真田樹義，河野寛，丸藤祐子，田中憲子，川上諒子，宮地元彦
  • Organizer: 第22回日本運動生理学会大会
  • Place of Presentation: 川崎医療福祉大学（岡山県）
  • Year and Date: 2014-07-20
• [Presentation] トレーニング様式の違いが中心動脈壁の粘性に及ぼす影響 (2014)
  • Author(s): 河野寛，丸藤祐子，村上晴香，宮地元彦
  • Organizer: 第22回日本運動生理学会大会
  • Place of Presentation: 川崎医療福祉大学（岡山県）
  • Year and Date: 2014-07-19
• [Presentation] Adverse Effects Of Coexistence Of Sarcopenia And Obesity On Cvd Risk Factors And Physical Activity Impairments In Japanese Adult Men (2014)
  • Author(s): Furushima T, Miyachi M, Iemitsu M, Murakami H, Kawano H, Gando Y, Kawakami R, Sanada K.
  • Organizer: 61st Annual Meeting of the American College of Sports Medicine
  • Place of Presentation: Orlando ,Florida (USA)
  • Year and Date: 2014-05-30
• [Presentation] Arterial Wall Viscosity Is Associated With Cardiorespiratory Fitness Independently Of Aging (2014)
  • Author(s): Kawano H, Yamamoto K, Gando Y, Tanimoto M, Murakami H, Ohmori Y, Sanada K, Tabata I, Higuchi M, Miyachi M.
  • Organizer: 61st Annual Meeting of the American College of Sports Medicine
  • Place of Presentation: Orlando ,Florida (USA)
  • Year and Date: 2014-05-29
• [Presentation] Estrogen Receptor-beta Gene Polymorphism Affects Carotid Arterial Elasticity and Wall Mass in Japanese Women (2014)
  • Author(s): Hayashi K, Iemitsu M, Murakami H, Sanada K, Kawano H, Gando Y, Tanaka N, Kawakami R, Miyachi M
  • Organizer: 61st Annual Meeting of the American College of Sports Medicine
  • Place of Presentation: Orlando ,Florida (USA)
  • Year and Date: 2014-05-29
• [Presentation] 加齢に伴う動脈壁の粘性増加は高心肺体力によって抑制される
  • Author(s): 河野寛、山元健太、丸藤祐子、村上晴香、真田樹義、樋口満、宮地元彦
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 東京
• [Presentation] 日本人女性におけるエストロゲン受容体β遺伝子多型と頸動脈コンプライアンスの関係
  • Author(s): 林貢一郎、家光素行、村上晴香、真田樹義、河野寛、丸藤祐子、田中憲子、川上諒子、宮地元彦
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 東京
• [Presentation] Influence of Sex on Streching Exercise-induced Reduction in Arterial Stiffness
  • Author(s): Gando Y, Yamamoto K, Kawano H, Hara R, Muraoka I.
  • Organizer: 18th Annual Congress of the European College of Sport Science
  • Place of Presentation: Barcelona, Spain
• [Presentation] Higher Cardiorespiratory Fitness Attenuates Arterial Stiffening Associated with the Estrogen Receptor-beta Polymorphism in Healthy Women
  • Author(s): Hayashi K, Iemitsu M, Murakami H, Sanada K, Kawano H, Gando Y, Tanaka N, Miyachi M
  • Organizer: 18th Annual Congress of the European College of Sport Science
  • Place of Presentation: Barcelona, Spain
• [Presentation] Greater Viscosity and Smaller Elasticity of Central Artery in Resistance-trained Young Men
  • Author(s): Kawano H, Gando Y, Asaka M, Ise R, Higuchi M
  • Organizer: 18th Annual Congress of the European College of Sport Science
  • Place of Presentation: Barcelona, Spain
• [Presentation] Ghrelin Leu72Met polymorphism affects a relationship between HDL cholesterol and cardiorespiratory fitness level in middle and older adults
  • Author(s): Kono S, Iemitsu M, Murakami H, Fujie S, Sanada K, Kawano H, Gando Y, Kawakami R, Yanaka N, Miyachi M
  • Organizer: 18th Annual Congress of the European College of Sport Science
  • Place of Presentation: Barcelona, Spain
• [Presentation] Bradycardia during Cold Face Test and Cardiovascular Disease Risk Factors in Swimmers and Controls
  • Author(s): Konishi M, Kawano H, Gando Y, Matsuda M, Sakamoto, Higuchi M
  • Organizer: 18th Annual Congress of the European College of Sport Science
  • Place of Presentation: Barcelona, Spain
• [Presentation] Cardiorespiratory fitness affects polymorphism in ADRB3 Trp64Arg-caused increase in common carotid intima-media thikness
  • Author(s): Fujie S, Iemitsu M, Murakami H, Sanada K, Kawano H, Gando Y, Kawakami R, Miyachi M
  • Organizer: Experimental Biology 2013
  • Place of Presentation: Boston, US