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Identification points of toxic yellow Tricholoma species which causes rhabdomyolysis

Research Project

Project/Area Number 25560409
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomolecular chemistry
Research InstitutionKeio University (2014-2016)
Kyoto Pharmaceutical University (2013)

Principal Investigator

Hashimoto Kimiko  慶應義塾大学, 理工学部(矢上), 特任准教授 (90286641)

Research Collaborator MORIMOTO Shigeo  
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsキシメジ / シモコシ / カラキシメジ / 見分け方 / 分類同定 / 横紋筋融解症 / 横紋筋融解 / キシメジ属 / 毒きのこ / ニセクロハツ / Tricholoma equestre
Outline of Final Research Achievements

Mushroom poisoning caused by Tricholoma equestre developed fatal rhabdomyolysis both in France and Poland. The T. equestre is a synonym of T. flavovirens known to distribute in Japan. In order to study the toxic principle of this mushroom, discrimination of this fungus from some similar species is essential.
For this purpose, the most complicated problem is absence of definite morphological information of each resembling fungi distribute in Japan. On investigation of possible Tricholoma species, discrimination of the following three yellow species, T. flavovirens, T. auratum, and T. aestuans was turned out to be the critical point. A kind of the host trees helps the discrimination, that is, T. auratum and T. aestuans grow in a coniferous forest, on the other hand, T. flavovirens do not depend on coniferous trees and grows in a broadleaf forest. Taste of the carpophore is another clue, that is, T. aestuans has a bitter taste and then produce a sharp taste on chewing.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Invited: 4 results)

  • [Journal Article] 毒のキシメジはどれ?2017

    • Author(s)
      橋本 貴美子
    • Journal Title

      札幌キノコの会会報

      Volume: 33 Pages: 3-6

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Identification of cyclopropylacetyl-(R)-carnitine, a unique chemical marker of the fatally toxic mushroom Russula subnigricans2016

    • Author(s)
      Masanori Matsuura, Suguru Kato, Yoko Saikawa, Masaya Nakata, and Kimiko Hashimoto
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64

    • NAID

      130005154407

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 毒きのこを探しています2015

    • Author(s)
      橋本貴美子
    • Organizer
      兵庫きのこの会合宿
    • Place of Presentation
      久米ロッジ(岡山県・津山市)
    • Year and Date
      2015-07-11
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] きのこ中毒あれこれ2015

    • Author(s)
      橋本貴美子
    • Organizer
      鳥取大学ポストグローバルCOEプログラム公開シンポジウム「毒きのこ-毒の秘密を科学する-」
    • Place of Presentation
      国立科学博物館(東京)
    • Year and Date
      2015-03-01
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ニセクロハツとその類似種2種2014

    • Author(s)
      橋本貴美子
    • Organizer
      関西菌類談話会535回例会
    • Place of Presentation
      日和田高原ロッジ(岐阜)
    • Year and Date
      2014-09-26
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 不安定な天然物の化学-ニセクロハツの毒成分研究2014

    • Author(s)
      橋本貴美子
    • Organizer
      有機合成協会、有機合成夏期セミナー 明日への有機合成化学
    • Place of Presentation
      大阪科学技術会センター(大阪)
    • Year and Date
      2014-08-29
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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