| Project/Area Number |
25560427
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic / Social brain science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
NIWA Yasutaka 独立行政法人理化学研究所, 生命システム研究センター, 基礎科学特別研究員 (40590071)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 睡眠覚醒 / Tetシステム / 行動異常 / ドキシサイクリン |
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| Outline of Final Research Achievements |
Starting to examine the detail about night-owl behavior of mutant mice, I realized that it is difficult to determine the condition of Dox administration by using those mice. This is because not all the mutant mice show night-owl behavior and LD to DD light conditioning is required to examine it. So I used different mutant mice which would be controllable by Dox administration and do show less weight and less sleep phenotypes. During this research period, I succeeded in inducing and reversing those phenotypes by just Dox administration via food. Based on the condition of those results, in the future, I will analyze night-owl behavior and determine when the behavior is determined to be repressed.
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