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The role of Lefty1 expression cells during the ES cell self-organization.

Research Project

Project/Area Number 25650079
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionOsaka University

Principal Investigator

TAKAOKA Katsuyoshi  大阪大学, 生命機能研究科, 助教 (90551044)

Project Period (FY) 2013-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords再生医療 / 自己組織化 / ES細胞 / 人工臓器 / 位置情報 / 未分化 / 非対称性の起源
Research Abstract

The acquirement of positional informations is essential for the making of structurally-complicated artificial organs. In mouse embryos, Lefty1 is a key player during the Left-right and anterior-posterior axis formation. And, it is known that Lefty1 is expressed is ES (Embryonic Stem) cells. In this study, I have tried to reveal the role of Lefty1 expression cells in the self-organization of ES cells.
As a result, time-lapse observations of Lefty1 expressing cells in the formation of colony showed that the expression of Lefty1 started in edge cells of the ES colony.
And, Lefty1,2 null ES cells normally formed colonies. Hereafter, I'm going to reveal which do Lefty1,2 null ES cells form embryoid bodies.

Report

(2 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (6 results)

All 2014

All Presentation (4 results) Book (2 results)

  • [Presentation] Origin of Anterior-Posterior axis formation in themouseembryo2014

    • Author(s)
      Katuyoshi Takaoka
    • Organizer
      第46回日本発生生物学会
    • Place of Presentation
      島根
    • Related Report
      2013 Final Research Report
  • [Presentation] Origin of Anterior-Posterior axis formation in the mouse embryo2014

    • Author(s)
      Katsuyoshi Takaoka& Hiroshi Hamada
    • Organizer
      NIBB岡崎カンファレンス
    • Place of Presentation
      愛知
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス胚における非対称性の起源2014

    • Author(s)
      高岡勝吉
    • Organizer
      発生生物学会秋期シンポジウム
    • Place of Presentation
      兵庫
    • Related Report
      2013 Final Research Report
  • [Presentation] Origin of Anterior-Posterior axis formation in the mouse embryo2014

    • Author(s)
      Katsuyoshi Takaoka& Hiroshi Hamada
    • Organizer
      分子生物学会
    • Place of Presentation
      兵庫
    • Related Report
      2013 Final Research Report
  • [Book] Establishment of Anterior-Posterior axis in the mouse embryo2014

    • Author(s)
      Katsuyoshi Takaoka
    • Publisher
      New Principles in Developmental Processes
    • Related Report
      2013 Final Research Report
  • [Book] New Principles in Developmental Processes2014

    • Author(s)
      Katsuyoshi Takaoka
    • Total Pages
      15
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report

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Published: 2014-07-25   Modified: 2016-11-25  

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