Virus resistance induced by Wolbachia

Research Project

Project/Area Number	25660262
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Insect science
Research Institution	Tohoku University
Principal Investigator	Ote Manabu 東北大学, 生命科学研究科, 研究支援者 (20386717)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	ボルバキア / ショウジョウバエ / ウイルス / RNA / 共生
Outline of Final Research Achievements	Based on the Serbus's report, I elucidated the possible involvement of RNA-binding proteins in the Wolbachia-induced phenomenon. It was revealed that Drosophila mutants of RNA-binding proteins phenocopy the host resistance to RNA viruses induced by Wolbachia. The RNA-binding proteins were colocalized with Wolbachia in somatic cells, implying the direct interaction of Wolbachia and the RNA-binding proteins. These findings raise the possibility that Wolbachia target the RNA-binding proteins for manipulation of host biology.

Report

(4 results)