Does treatment of blood flow decrease, a complication of neuropathic pain, can be a target of pain palliation?
| Project/Area Number |
25670041
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
Saito Shin-ya 静岡県立大学, 薬学部, 准教授 (80271849)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 神経因性疼痛 / 皮膚血管 / 電位依存性Caチャネル / Na/Ca交換体 / 血管拡張 / 温度依存性 / 疼痛緩和 / 温度感受性 / CCI動物 / ラット足底動脈 / ラット尾動脈 / ラット総腸骨動脈 / KB-R 7943 / α1受容体 / LOE908 |
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| Outline of Final Research Achievements |
Dependence on voltage-dependent Ca channel (VDCC) is relatively low in skin artery comparing with other arteries. This may account for its tolerance on low temperature, since activity of VDCC is decrease in low temperature. In sciatic nerve-injured model rat, damage of sympathetic nerve is accompanied with decrease of Ca extrusion in planter artery, which results in increase of response to contractile stimuli. This suggests that weak stimuli are enough to induce sufficient contraction in injured site. According to this opinion, we administrated low dose of vasodilator which showed vasodilation with increase in pain threshold. In this study, we demonstrated that treatments which cause vasodilating response can be tools for treatment of pain.
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Report
(4 results)
Research Products
(10 results)
