Design and synthesis of phosphatidylserine dimers with antitumor effect via the phagocytosis-inducing property
| Project/Area Number |
25670048
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
SHUTO satoshi 北海道大学, 薬学研究科(研究院), 教授 (70241346)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDA Hayato 北海道大学, 薬学研究科(研究院), 助教 (30434450)
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| Co-Investigator(Renkei-kenkyūsha) |
ASAI Akira 静岡県立大学, 大学院薬学研究科, 教授 (60381737)
MATSUDA Tadashi 北海道大学, 薬学研究科(研究院), 教授 (20212219)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ホスファチジルセリン / ファゴサイトーシス / 二量等価体 / クアトロフェニル |
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| Outline of Final Research Achievements |
We designed and synthesized dimer derivatives of phosphatidylserine as phagocytosis inducer via exposure of phosphor-serine polar-head moieties on cell surface, which are potentially used in immune cancer therapy. We successfully synthesized these dimer derivatives. We demonstrated that the liposomes containing the synthesized dimer derivatives of phosphatidylserine actually exposed the phosphor-serine polar-head moieties on cell surface in the evaluation with tumor cells.
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Report
(3 results)
Research Products
(1 results)
