Research Project
Grant-in-Aid for Challenging Exploratory Research
Cardiotoxicity of drugs is the main cause of drop out from the pipeline and recall from the market. Thus, the development of assay system, especially in vitro assay system in the early stage of drug development, has been strongly required from pharmaceutical companies. Here, we used multi-electrode array (MEA) system and motion vector prediction (MVP) system developed by the Sony coorporation to establish the system to simultaneously assay electrical activity and contractility in cardiomyocytes. We confirmed in human iPS-derived cardiomyocytes that drugs known to possess positive and negative inotropic effects could be reliably assayed. Recently, the cardiotoxicity of anti-cancer drugs has been strongly concerned. We successfully assayed cardiotoxicity of anticancer drugs.
All 2015 2014 2013 Other
All Journal Article (2 results) (of which Peer Reviewed: 2 results, Open Access: 2 results, Acknowledgement Compliant: 1 results) Presentation (25 results) (of which Invited: 6 results) Book (2 results)
J Mol Cell Cardiol
Volume: 77 Pages: 178-191
10.1016/j.yjmcc.2014.09.010
J Am Heart Assoc
Volume: 3 Issue: 6 Pages: 1-25
10.1161/jaha.114.001263
