Research Project
Grant-in-Aid for Challenging Exploratory Research
We have identified MHC class II molecules as a molecule that transports cellular misfolded MHC class I molecules to the cell surface. When we analyzed other proteins, hen egg lysozeme, immunoglobulin heavy chain and β2-glycoprotein I were also transported to the cell surface by MHC class II molecules upon association with MHC class II molecules. Furthermore, these misfolded proteins transported to the cell surface by MHC class II molecules were found to be specific targets for autoantibodies produced in rheumatoid arthritis and antiphospholipid syndrome. In order to identify molecules that transport misfolded proteins to the cell surface, we analyzed molecules that associate with misfolded proteins at the cell surface. We found that several molecules are associated with misfolded proteins by mass spectrometry.
All 2015 2014 2013 Other
All Journal Article (16 results) (of which Peer Reviewed: 12 results, Acknowledgement Compliant: 1 results, Open Access: 3 results) Presentation (39 results) (of which Invited: 17 results) Book (4 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)
Blood
Volume: 125 Issue: 18 Pages: 2835-2844
10.1182/blood-2014-08-593624
臨床免疫・アレルギー科
Volume: 63(2) Pages: 187-192
Int. Immunol.
Volume: - Issue: 6 Pages: 307-314
10.1093/intimm/dxv004
週刊医学のあゆみ 「HLAのブレイクスルー ー臨床応用と疾患研究の進歩」
Volume: 251(4) Pages: 283-288
Microbiol Immunol.
Volume: 58(9) Issue: 9 Pages: 513-522
10.1111/1348-0421.12180
40020207309
Blood.
Volume: 124(6) Issue: 6 Pages: 924-935
10.1182/blood-2014-01-549162
感染・炎症・免疫
Volume: 44(2) Pages: 67-69
細胞工学
Volume: 33(7) Pages: 762-763
Proc Natl Acad Sci U S A.
Volume: 111(24) Issue: 24 Pages: 8877-8882
10.1073/pnas.1324105111
Ann. N. Y. Acad. Sci.
Volume: in press
Proceedings of National Academy of Science USA
Volume: 111 Issue: 10 Pages: 3787-3792
10.1073/pnas.1401105111
Cell
Volume: 156 Issue: 6 Pages: 1223-1234
10.1016/j.cell.2014.01.069
Scientific Reports
Volume: 3 Issue: 1 Pages: 2669-2669
10.1038/srep02669
PLos One
Volume: 8 Issue: 8 Pages: e72050-e72050
10.1371/journal.pone.0072050
J Virol.
Volume: 87(19) Issue: 19 Pages: 10900-10903
10.1128/jvi.01427-13
Br. J. Dermatol.
Volume: 169 Issue: 1 Pages: 201-204
10.1111/bjd.12265
http://immchem.biken.osaka-u.ac.jp
http://immchem.biken.osaka-u.ac.jp/