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Regulatory mechanisms of cancer soontaneous regression

Research Project

Project/Area Number 25670163
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionNagoya University

Principal Investigator

KADOMATSU Kenji  名古屋大学, 医学(系)研究科(研究院), 教授 (80204519)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords自然退縮 / がん / 神経芽腫
Outline of Final Research Achievements

Spontaneous regression is an intriguing phenomenon which is linked to the development of therapy of cancers. We found spontaneous regression in the neuroblastoma model MYCN Tg mice.
In this study, we could culture spheres from all specimen at early cancer stage, i.e., 2 weeks after birth. Furthermore, we succeeded sphere culture of embryonic sympathetic ganglia of MYCN Tg mice. Using these samples, we should be able to perform analyses at genome, epigenome and transcriptome levels, which may in turn lead to elucidation of mechanisms underlying cancer development and spontaneous regression.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Invited: 2 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Atelocollagen-Mediated Intravenous siRNA Delivery Specific to Tumor Tissues Orthotopically Xenografted in Prostates of Nude Mice and Its Anticancer Effects.2015

    • Author(s)
      Yuan Y, Makita N, Cao D, Mihara K, Kadomatsu K, Takei Y.
    • Journal Title

      Nucleic Acid Ther.

      Volume: 25 Issue: 2 Pages: 85-94

    • DOI

      10.1089/nat.2014.0526

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NeuroD1 promotes neuroblastoma cell growth by inducing the expression of ALK.2015

    • Author(s)
      Lu F, Kishida S, Mu P, Huang P, Cao D, Tsubota S, Kadomatsu K.
    • Journal Title

      Cancer Science

      Volume: in press Issue: 4 Pages: 390-396

    • DOI

      10.1111/cas.12628

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EML4 promotes the loading of NUDC to the spindle for mitotic progression.2015

    • Author(s)
      Chen D, Ito S, Yuan H, Hyodo T, Kadomatsu K, Hamaguchi M, Senga T.
    • Journal Title

      Cell Cycle.

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation.2015

    • Author(s)
      Nakaguro M, Kiyonari S, Kishida S, Cao D, Murakami-Tonami Y, Ichikawa H, Takeuchi I, Nakamura S, Kadomatsu K
    • Journal Title

      Cancer Science

      Volume: 106 Issue: 3 Pages: 237-243

    • DOI

      10.1111/cas.12598

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuroblastoma models for insights into tumorigenesis and new therapies.2015

    • Author(s)
      Kiyonari S, Kadomatsu K.
    • Journal Title

      Expert Opin Drug Discov.

      Volume: 10 Issue: 1 Pages: 53-62

    • DOI

      10.1517/17460441.2015.974544

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells.2014

    • Author(s)
      Murakami-Tonami Y, Kishida S, Takeuchi I, Katou Y, Maris JM, Ichikawa H, Kondo Y, Sekido Y, Shirahige K, Murakami H, Kadomatsu K.
    • Journal Title

      Cell Cycle.

      Volume: 13 Issue: 7 Pages: 1115-1131

    • DOI

      10.4161/cc.27983

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new tumorsphere culture condition restores potentials of self-renewal and metastasis of primary neuroblastoma in a mouse neuroblastoma model.2014

    • Author(s)
      Cao D, Kishida S, Huang P, Mu P, Tsubota S, Mizuno M, Kadomatsu K.
    • Journal Title

      PLoS One.

      Volume: 9

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Midkine : an emerging target of drug development for treatment of multiple diseases2014

    • Author(s)
      Muramatsu T, Kadomatsu K
    • Journal Title

      Br J Pharmacol

      Volume: 171(4) Issue: 4 Pages: 811-813

    • DOI

      10.1111/bph.12571

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic potential of midkine in cardiovascular disease2014

    • Author(s)
      Kadomatsu K, Bencsik P, Görbe A, Csonka C, Sakamoto K, Kishida S, Ferdinandy P
    • Journal Title

      Br J Pharmacol

      Volume: 171(4) Issue: 4 Pages: 936-944

    • DOI

      10.1111/bph.12537

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of midkine in neuroblastoma tumourigenesis2014

    • Author(s)
      Kishida S, Kadomatsu K
    • Journal Title

      Br J Pharmacol

      Volume: 171(4) Issue: 4 Pages: 896-904

    • DOI

      10.1111/bph.12442

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of midkine in normal human skin, dermatitis and neoplasms: association with differentiation of keratinocytes.2013

    • Author(s)
      Monma F, Hozumi Y, Ikematsu S, Kawaguchi M, Kadomatsu K, Suzuki T.
    • Journal Title

      J Dermatol.

      Volume: 40 Issue: 12 Pages: 980-986

    • DOI

      10.1111/1346-8138.12333

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Discovering combinatorial interactions in survival data2013

    • Author(s)
      David duVerle, Ichiro Takeuchi, Yuko Murakami-Tonami, Kenji kadomatsu, Koji Tsuda
    • Journal Title

      Bio in formatics

      Volume: 23 Issue: 23 Pages: 3053-3059

    • DOI

      10.1093/bioinformatics/btt532

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Midkine overcomes neurite outgrowth inhibition of chondroitin sulfate proteoglycan without glial activation and promotes functional recovery after spinal cord injury.2013

    • Author(s)
      Muramoto A, Imagama S, Natori T, Wakao N, Ando K, Tauchi R, Hirano K, Shinjo R, Matsumoto T, Ishiguro N, Kadomatsu K.
    • Journal Title

      Neurosci Lett.

      Volume: 550 Pages: 150-155

    • DOI

      10.1016/j.neulet.2013.06.025

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The heparin-binding growth factor midkine : the biological activities and candidate receptors2013

    • Author(s)
      Kadomatsu K, Kishida S, Tsubota S
    • Journal Title

      J Biochem

      Volume: 153(6) Issue: 6 Pages: 511-521

    • DOI

      10.1093/jb/mvt035

    • NAID

      40019655639

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Biomedical research at Nagoya University: International joint symposium Nagoya University

    • Author(s)
      Kadomatsu, K.
    • Organizer
      University of Adelaide, University of Freiburg,
    • Place of Presentation
      Nagoya University, Nagoya
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 糖鎖と神経の融合研究へ ~硫酸化糖鎖と神経回路再編~

    • Author(s)
      門松健治
    • Organizer
      生化学会大会シンポジウム「脳神経回路の可塑性の生化学研究:分子メカニズムから疾患まで
    • Place of Presentation
      横浜国際会議場、横浜
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] Sugar Chains2015

    • Author(s)
      Kishida S, Kadomatsu K.
    • Total Pages
      288
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Remarks] 名古屋大学大学院医学系研究科分子生物学

    • URL

      http://www.med.nagoya-u.ac.jp/biochem/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 名古屋大学大学院医学系研究科分子生物学

    • URL

      http://www.med.nagoya-u.ac.jp/biochem

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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