| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
It has been suggested that microRNA plays a crucial role in stress coping reactions. In this project, we succeeded to identify chronic psychological stress-responsive microRNAs (miR-16, miR-20b, miR-26b, miR-29a, miR126, miR-144, miR-144*) (PLoS One, 2013). We have also identify an anxiety and/or depression-associated miR-144 in healthy medical staffs of private hospitals. In addition, we examined differentially expressed microRNAs in peripheral blood from patients with chronic fatigue syndrome, and we revealed 6 microRNASs differentially expressed in those patients. Using the Target scan software, we found that the differentially expressed microRNAs significantly augmented inflammatory reaction and suppressed the protein synthesis pathway. Our results suggest that distinct microRNAs in peripheral blood may be useful for assessment of stress responses in healthy subjects and for diagnosis of pathological fatigue.
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