A Novel strategy of radiosensitization using titan peroxide nanoparticles

• Project/Area Number: 25670535
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: SASAKI RYOHEI 神戸大学, 医学部附属病院, 教授 (30346267)
• Co-Investigator(Kenkyū-buntansha): OGINO Chiaki 神戸大学, 工学(系)研究科(研究院), 准教授 (00313693) ; SATO Kazuyoshi 群馬大学, その他(部局等), 助教 (40437299) ; NUMAKO Chiya 千葉大学, 理学(系)研究科(研究院), 准教授 (80284280) ; NAKAYAMA Masao 神戸大学, 医学(系)研究科(研究院), 研究員 (60582004) ; AKASAKA Hiroaki 神戸大学, 医学部附属病院, 助教 (20707161)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 放射線増感 / ナノ粒子 / 放射線療法 / 活性酸素腫 / 膵臓がん / ROS

Outline of Final Research Achievements

The tumor growth inhibitory effects ofPAA-TiOx nanoparticles combined with X-ray irradiation was observed in vitro and in vivo experiments.The effect was induced by ROS generation followed by DNA damages in cancer cells. Evaluations of long-term toxicity and of molecular mechanisms need to be performed in the nearest future. This strategy might be a novel radiosensitization method using metal nanoparticles

Research Products

• [Journal Article] FDG-PET/contrast-enhanced CT as a post-treatment tool in head and neck squamous cell carcinoma: comparison with FDG-PET/non-contrast-enhanced CT and contrast-enhanced CT. (2016)
  • Author(s): Suenaga Y, Kitajima K, Ishihara T, Sasaki R, Otsuki N, Nibu KI, Minamikawa T, Kiyota N, Sugimura K.
  • Journal Title: Eur Radiol. Volume: 26(4) Issue: 4 Pages: 1018-1030
  • DOI: 10.1007/s00330-015-3902-1
  • Peer Reviewed
• [Journal Article] [(18)F]-FDG PET/CT imaging for detection of nodal metastases in patients with squamous cell carcinoma of the pharynx and larynx: comparison with CT. (2016)
  • Author(s): Suenaga Y, Kitajima K, Kanda T, Otsuki N, Nibu K, Sasaki R, Itoh T, Sugimura K.
  • Journal Title: Jpn J Radiol. Volume: 34 Issue: 3 Pages: 203-210
  • DOI: 10.1007/s11604-015-0510-6
  • NAID: 210000165125
  • Peer Reviewed / Open Access
• [Journal Article] Concomitant chemoradiotherapy for advanced squamous cell carcinoma of temporal bone (2016)
  • Author(s): Shinomiya H, Hasegawa S, Yamashita D, Ejima Y, Kenji Y, Otsuki N, Kiyota N, Sakakibara S, Nomura T, Hashikawa K, Kohmura E, Sasaki R, Nibu KI.
  • Journal Title: Head Neck. Volume: 38 Suppl 1 Issue: S1
  • DOI: 10.1002/hed.24133
  • Peer Reviewed
• [Journal Article] Particle therapy for clinically diagnosed stage I lung cancer: comparison with pathologically proven non-small cell lung cancer. (2015)
  • Author(s): 6.Fujii O, Demizu Y, Hashimoto N, Takagi M, Terashima K, Mima M, Jin D, Nagano F, Katsui K, Okimoto T, Iwata H, Niwa Y, Yamashita T, Akagi T, Daimon T, Sasaki R, Hishikawa Y, Abe M, Murakami M, Fuwa N.
  • Journal Title: Acta Oncol. Volume: 54(3) Issue: 3 Pages: 315-321
  • DOI: 10.3109/0284186x.2014.974828
  • Peer Reviewed
• [Journal Article] The current status and future of radiotherapy for spinal bone metastases. (2015)
  • Author(s): Ejima Y, Matsuo Y, Sasaki R.
  • Journal Title: J Orthop Sci. Volume: 20(4) Issue: 4 Pages: 585-592
  • DOI: 10.1007/s00776-015-0720-x
  • Peer Reviewed
• [Journal Article] Assessment of Parametrial Response by Growth Pattern in Patients With International Federation of Gynecology and Obstetrics Stage IIB and IIIB Cervical Cancer: Analysis of Patients From a Prospective, Multicenter Trial (EMBRACE). (2015)
  • Author(s): 17.Yoshida K, Jastaniyah N, Sturdza A, Lindegaard J, Segedin B, Mahantshetty U, Rai B, Jürgenliemk-Schulz I, Haie-Meder C, Sasaki R, Pötter R.
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 93(4) Issue: 4 Pages: 788-796
  • DOI: 10.1016/j.ijrobp.2015.08.007
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment. (2015)
  • Author(s): Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y, Masui K, Gini B, Yang H, Hosoda K, Sasaki R, Mischel PS, Kohmura E.
  • Journal Title: J Clin Invest Volume: 125 Issue: 4 Pages: 1591-602
  • DOI: 10.1172/jci78239
  • Peer Reviewed / Open Access
• [Journal Article] Treatment Outcomes of Particle Radiotherapy Using Protons or Carbon Ions as a Single-Modality Therapy for Adenoid Cystic Carcinoma of the Head and Neck (2014)
  • Author(s): Masaru Takagi,Yusuke Demizu, Naoki Hashimoto, Masayuki Mima, Kazuki Terashima, Osamu Fujii, Dongcun Jin, Yasue Niwa, Koichi Morimoto, Takashi Akagi, Takashi Daimon, Ryohei Sasaki, Yoshio Hishikawa, Mitsuyuki Abe, Masao Murakami, and Nobukazu Fuwa
  • Journal Title: Radiotherapy and Oncology, Volume: 113(3) Issue: 3 Pages: 364-370
  • DOI: 10.1016/j.radonc.2014.11.031
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Preclinical Evaluation of Bioabsorbable Polyglycolic Acid (PGA) Spacer for Particle Therapy (2014)
  • Author(s): Hiroaki Akasaka, Ryohei Sasaki, Daisuke Miyawaki, Naritoshi Mukumoto, Nor Shazrina Binti Sulaiman, Masaaki Nagata, Shigeru Yamada, Masao Murakami, Yusuke Demizu, Takumi Fukumoto
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 90(5) Issue: 5 Pages: 1177-1185
  • DOI: 10.1016/j.ijrobp.2014.07.048
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prognostic Value of FDG PET Imaging in Patients with Laryngeal Cancer (2014)
  • Author(s): Kitajima K, Suenaga Y, Kanda T, Miyawaki D, Yoshida K, Ejima Y, Sasaki R, Komatsu H, Saito M, Otsuki N, Nibu K, Kiyota N, Minamikawa T, Sugimura K.
  • Journal Title: PLoS One Volume: 9(5) Issue: 5 Pages: e96999-e96999
  • DOI: 10.1371/journal.pone.0096999
  • NAID: 120005603819
  • Peer Reviewed / Open Access
• [Journal Article] Particle beam radiation therapy using carbon ions and protons for oligometastatic lung tumors. (2014)
  • Author(s): Sulaiman NS, Fujii O, Demizu Y, Terashima K, Niwa Y, Akagi T, Daimon T,Murakami M, Sasaki R, Fuwa N.
  • Journal Title: Radiat Oncol. Volume: 9 Issue: 1 Pages: 183-183
  • DOI: 10.1186/1748-717x-9-183
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transcutaneous application of CO2 enhances the antitumor effect of radiation therapy in human malignant fibrous histiocytoma. (2014)
  • Author(s): Onishi Y, Akisue T, Kawamoto T, Ueha T, Hara H, Toda M, Harada R, Minoda M, Morishita M, Sasaki R, Nishida K, Kuroda R, Kurosaka M
  • Journal Title: Int J Oncol. Volume: 45(2) Issue: 2 Pages: 732-738
  • DOI: 10.3892/ijo.2014.2476
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Particle therapy using carbon ions or protons as a definitive therapy for patients with primary sacral chordoma. (2014)
  • Author(s): Mima M, Demizu Y, Jin D, Hashimoto N, Takagi M, Terashima K, Fujii O, Niwa Y, Akagi T, Daimon T, Hishikawa Y, Abe M, Murakami M, Sasaki R, Fuwa N.
  • Journal Title: Br J Radiol. Volume: 87(1033) Issue: 1033 Pages: 20130512-20130512
  • DOI: 10.1259/bjr.20130512
  • Peer Reviewed / Open Access
• [Journal Article] Effect of heterogeneity correction on dosimetric parameters of radiotherapy planning for thoracic esophageal cancer. (2013)
  • Author(s): Nakayama M, Yoshida K, Nishimura H, Miyawaki D, Uehara K, Okamoto Y, Okayama T, Sasaki R.
  • Journal Title: Med Dosim. Volume: 39(1) Issue: 1 Pages: 31-3
  • DOI: 10.1016/j.meddos.2013.09.001
  • Peer Reviewed / Open Access
• [Journal Article] Current status and future of the radiotherapy for pancreas cancer (2013)
  • Author(s): Sasaki R, Miyawaki D.
  • Journal Title: Nihon Shokakibyo Gakkai Zasshi. 2013 Volume: 110(12) Pages: 2073-80
  • NAID: 130003383326
• [Journal Article] Value of retrospective image fusion of ¹⁸F-FDG PET and MRI for preoperative staging of head and neck cancer: comparison with PET/CT and contrast-enhanced neck MRI. (2013)
  • Author(s): Kanda T, Kitajima K, Suenaga Y, Konishi J, Sasaki R, Morimoto K, Saito M, Otsuki N, Nibu K, Sugimura K.
  • Journal Title: Eur J Radiol Volume: 82(11) Issue: 11 Pages: 2005-10
  • DOI: 10.1016/j.ejrad.2013.06.025
  • Peer Reviewed
• [Journal Article] Monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach enhances the anti-cell proliferation effect of gemcitabine in human pancreatic cancer cells. (2013)
  • Author(s): Akasaka H, Sasaki R, Yoshida K, Takayama I, Yamaguchi T, Yoshida H, Mizushina Y.
  • Journal Title: Biochim Biophys Acta. Volume: 1830(3) Pages: 2517-25
  • Peer Reviewed
• [Journal Article] Long-Term Outcome of Proton Therapy and Carbon-Ion Therapy for Large (T2a-T2bN0M0) Non-Small-Cell Lung Cancer (2013)
  • Author(s): Iwata H, Demizu Y, Fujii O, Terashima K, Mima M, Niwa Y, Hashimoto N, Akagi T, Sasaki R,Hishikawa Y, Abe M, Shibamoto Y, Murakami M, Fuwa N
  • Journal Title: J Thorac Oncol Volume: Epub ahead of print Issue: 6 Pages: 726-35
  • DOI: 10.1097/jto.0b013e318288ab02
  • Peer Reviewed
• [Journal Article] Evaluation of absorbed dose from kilovoltage cone-beam computed tomography by radiotherapy planning system: influence on the radiation therapy for prostate cancer (2013)
  • Author(s): Kawamura T, Murakami N, Okamura Y, Nishimura H, Miyawaki D, Kimura K, Hase M, Sasaki R.
  • Journal Title: Nihon Hoshasen Gijutsu Gakkai Zasshi. Volume: 69(5) Pages: 491-9
  • NAID: 10031159475
  • Peer Reviewed
• [Journal Article] Pelvic insufficiency fracture after definitive radiotherapy for uterine cervical cancer: retrospective analysis of risk factors. (2013)
  • Author(s): Uezono H, Tsujino K, Moriki K, Nagano F, Ota Y, Sasaki R, Soejima T.
  • Journal Title: J Radiat Res. Volume: 54(6) Issue: 6 Pages: 1102-9
  • DOI: 10.1093/jrr/rrt055
  • Peer Reviewed
• [Presentation] Hypofractionated Stereotactic radiotherapy Compared with Stereotactic Radiosurgery for brain metastases from Lung Cancer: Experience at a Single Institution (2015)
  • Author(s): "Takeaki Ishihara, Kazunari Yamada Yasuo Ejima, Kenji Yoshida, Daisuke Miyawaki ,Haruka Uezono, Shazrina Sulaiman, Yoshirou Matsuo, Ryo Nishikawa and Ryohei Sasaki
  • Organizer: 57th Annual Meeting of ASTRO
  • Place of Presentation: San Antonio, USA
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: a Dose-Volume Histogram Analysis (2015)
  • Author(s): D. Miyawaki, N. Mukumoto, Y. Ejima, K. Yoshida, T. Ishihara, N. Kiyota, M. Saito, N. Otsuki, K. Nibu, R. Sasaki
  • Organizer: European Cancer Congress 2015
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2015-09-25
  • Int'l Joint Research
• [Presentation] Titanium peroxide nanoparticles, as novel radiosensitizers, enhance antitumor efficacy in pancreatic cancer therapy (2015)
  • Author(s): Masao Nakayama, Ryohei Sasaki, Chiaki Ogino, Tsutomu Tanaka, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Kazuyoshi Sato, Chiya Numako, Seiichi Takami, Akihiko Kondo
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Radiosensitizor extracted from Spinach, MGDG, Enhanced the Cytotoxic Effect for Pancreatic Cancer Cells when combined with Radiation Treatment (2015)
  • Author(s): Hiroaki Akasaka, Yasuo Ejima, Kenji Yoshida, Daisuke Miyawaki, Takeaki Ishihara, Yoshiyuki Mizushina and Ryohei Sasaki
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Titanium peroxide nanoparticles enhance antitumor efficacy through reactive oxygen species in pancreatic cancer radiation therapy (2015)
  • Author(s): Masao Nakayama, Ryohei Sasaki, Toru Mukohara, Chiaki Ogino, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Kazuyoshi Sato, Chiya Numako, Seiichi Takami, Akihiko Kondo
  • Organizer: AACR Annual Meeting 2015
  • Place of Presentation: Philadelphia, US
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] A Novel Method for Space Modulated Radiotherapy (SMRT):Nonwoven fabric polyglycolic acid (PGA) spacer (2014)
  • Author(s): R Sasaki, H Akasaka, D Miyawaki, Nor Shazrina Sulaiman, Y Demizu, S Yamada, M Murakami, T Fukumoto
  • Organizer: The 15th Asian Oceanian Congress of Radiology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2014-09-24 – 2014-09-28
• [Presentation] Assessment of Correlation and Prediction Errors of the CyberKnife Synchrony Respiratory Tracking Ststem for the Treatment of Liver Tumors (2014)
  • Author(s): M Nakayama, T Ogata, K Uehara, H Nishimura, H Mayahara, A Harada, Y Matsuo, Y Ejima, D Miyawaki, R Sasaki, J Ishida , M Fujii
  • Organizer: The 15th Asian Oceanian Congress of Radiology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2014-09-24 – 2014-09-28
• [Presentation] Dose Estimation Of Normal Brain Tissue Tolerance For Microbeam Radiation Therapy (2014)
  • Author(s): M Nakayama, N Mukumoto, H Akasaka, D Miyawaki, H Nishimura, K Umetani, N Nariyama, T Kondoh, K Shinohara, R Sasaki
  • Organizer: ASTRO’s 56th Annual Meeting
  • Place of Presentation: San Francisco USA
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Intra-abdomical space modulated radiotherapy: Safety and efficacy of absorbable spacer in particle therapy (2014)
  • Author(s): R. Sasaki, H. Akasaka, D. Miyawaki, N.S. Sulaiman, Y. Demizu, S. Yamada, M. Murakami, T. Fukumoto
  • Organizer: ESTRO
  • Place of Presentation: Vienna，Austria
  • Year and Date: 2014-04-04 – 2014-04-08
• [Presentation] A Novel method of Radioprotection for the Gastointestinal System: Efficacy of the Reduced form of Coenzyme Q10. (2013)
  • Author(s): Ryohei Sasaki, Nelly Nelly, Naritoshi Mukumoto, Hiroaki Akasaka, Nor Shazrina Sulaiman, Daisuke Miyawaki, Kenji Yoshida, Yasuo Ejima
  • Organizer: 55th Annual meeting ASTRO
  • Place of Presentation: Atlanta, USA
• [Presentation] Normal tissue tolerance of microplanar beam X-ray : A long-term observation (2013)
  • Author(s): Naritoshi Mukumoto, Daisuke Miyawaki, Hiroaki Akasaka, Masao Nakayama, Yasushi Miura, Keiji Umetani, Nobuteru Nariyama, Kunio Shinohara, Takeshi Kondoh and Ryohei Sasaki
  • Organizer: 55th Annual meeting ASTRO
  • Place of Presentation: Atlanta, USA
• [Presentation] Roles of FDG-PET for Non-Small-Cell Lung Cancer (2013)
  • Author(s): R Sasaki, R Komaki
  • Organizer: 37th Annual MD Anderson Radiation Oncology/Gilbert H. Fletcher Society Meeting
  • Place of Presentation: Kyoto Japan
• [Presentation] A Novel Radiosensitizor of the Functional Food Component, Monogalactosyl diacylglycerol (MGDG) from Spinach, Enhanced the Cytotoxic Effects for the Pancreatic Cancer In Vitro and In Vivo (2013)
  • Author(s): H. Akasaka, R. Sasaki, N. Mukumoto, M. Nakayama, N.S. Sulaiman, D. Miyawaki, K. Yoshida, Y. Ejima, Y. Mizushina
  • Organizer: 55th Annual meeting ASTRO
  • Place of Presentation: Atlanta, USA
• [Book] Non-woven Fabrics (ISBN 978-953-51-2271-5) (2016)
  • Author(s): Ryohei Sasaki, Hiroaki Akasaka, Yusuke Demizu, Sachiko Inubushi, Tianyuan Wang, Takumi Fukumoto.
  • Total Pages: 315
  • Publisher: INTECH
• [Book] 多職種チームで実践する頭頚部がんの化学放射線療法 (2015)
  • Author(s): 丹生健一、佐々木良平、大月直樹、大田史江
  • Total Pages: 272
  • Publisher: 日本看護協会出版会
• [Patent(Industrial Property Rights)] Radiation therapy agent (2013)
  • Inventor(s): OGINO, C; TANAKA, T;SASAKI, R
  • Industrial Property Rights Holder: UNIV.CORPOR. KOBE UNIVERSITY
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-11-12
  • Overseas