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The elucidation of novel T cell function in innate immunity-dominated liver tissue damage.

Research Project

Project/Area Number 25670590
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionThe Tazuke Kofukai

Principal Investigator

TERAJIMA Hiroaki  公益財団法人田附興風会, 医学研究所 第1研究部, 研究主幹 (40314215)

Co-Investigator(Kenkyū-buntansha) UCHIDA Yoichiro  公益財団法人田附興風会, 医学研究所第1研究部, 主任研究員 (30597745)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords肝虚血再灌流障害 / galectin-9 / Tim-3 / 虚血再還流障害 / 肝臓 / T細胞 / TIM-3 / TLR-4 / マクロファージ / 虚血再灌流障害 / TIM / Galectin-9
Outline of Final Research Achievements

Liver ischemia reperfusion injury (IRI) is still an important problem in liver transplantation, and is affected by T-cell / Macrophage interaction. We have focused on Tim-3 / Galectin-9 pathway as regulatory system in liver IRI. The expression of Gal-9 was enhanced endogenously in liver especially by hepatocytes and Kupffer cells during warm IRI for a mouse liver. Exogenously administered reGal-9 significantly ameliorated hepatocellular damage due to IR. In the circumstance of Gal-9 absence, the liver damage exacerbated the severity as compared with wild type. The severe liver damage in Gal-9 KO mice was improved by the administration of reGal-9. Our study suggests a significant role of Gal-9 in the maintenance of hepatic homeostasis, and exogenous Gal-9 treatment will be a new therapeutic strategy against liver IRI.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] The protective function of galectin-9 in liver ischemia and reperfusion injury in mice.2015

    • Author(s)
      Hirofumi Hirao, Yoichiro Uchida, Kentaro Kadono, Hirokazu Tanaka, Toshiro Niki, Akira Yamauchi, Koichiro Hata, Takeshi Watanabe, Hiroaki Terajima, Shinji Uemoto
    • Journal Title

      Liver Transplantation

      Volume: 21 Issue: 7 Pages: 969-981

    • DOI

      10.1002/lt.24159

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 肝虚血再灌流障害と自然免疫の新しいメカニズムの解明―T cell Macrophage Cross-Talk―2015

    • Author(s)
      内田 洋一朗、平尾 浩史、門野 賢太郎、田中 宏和、吉冨 摩美、飯田 拓、上田 修吾、金澤 旭宣、上本 伸二、寺嶋 宏明
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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