Association between carcinogenesis of the cervix and HLA class II polymorphism.
Project/Area Number |
25670693
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | University of Tsukuba |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
MAEDA Hiroo 埼玉医科大学, 医学部, 教授 (30134597)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 子宮頸がん / ヒトパピローマウイルス(HPV) / ヒト白血球型抗原(HLA) / ヒトパピローマウイルス(HPV) / ヒト白血球型抗原(HLA) / ヒトパピローマウイルス (HPV) / ヒト白血球型抗原 (HLA) |
Outline of Final Research Achievements |
The aim was to investigate associations between HLA class II alleles and risks of cervical cancer in a Japanese population. A cross-sectional analysis for HLA association with cervical cancer included 1253 Japanese women: normal cytology (n=341), CIN1/2 (n=591), and CIN3 or invasive cervical cancer (n=321). Furthermore, the CIN1/2 cases were prospectively monitored to analyze cumulative probability of progression to CIN3. Compared with women with normal cytology or CIN1/2, DRB1*0901 and DRB1*1302 frequencies were significantly decreased among women with CIN3/ICC (P=0.00001 and P=0.006, respectively). Based on follow-up data of 454 women with CIN1/2, the risk of progression to CIN3 within the next 10 years was significantly reduced among DRB1*1302-positive women (3.2% vs. 23.7%, P=0.03),. CONCLUSION: By using cross-sectional and prospective study designs, we demonstrated the protective effect of the DRB1*1302 allele against progression to CIN3/ICC. 965
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Report
(3 results)
Research Products
(72 results)
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[Journal Article] Administration of standard-dose BEP regimen (bleomycin+etoposide+cisplatin) is essential for treatment of ovarian yolk sac tumour2015
Author(s)
Satoh T, Aoki Y, Kasamatsu T, Ochiai K, Takano M, Watanabe Y, Kikkawa F, Takeshima N, Hatae M, Yokota H, Saito T, Yaegashi N, Kobayashi H, Baba T, Kodama S, Saito T
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Journal Title
Eur J Cancer
Volume: 51
Issue: 3
Pages: 340-51
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[Journal Article] Pathology-oriented treatment strategy of malignant ovarian tumor in pregnant women: analysis of 41 cases in Japan.2014
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Morikawa A, Ueda K, Takahashi K, Fukunaga M, Iwashita M, Kobayashi Y, Takechi K, Umezawa S, Terauchi F, Kiguchi K, Aoki D, Nomura H, Yoshikawa H, Satoh T, Jobo T, Fujiwara H, Takei Y, Kamoi S, Terao Y, Isonishi S.
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Journal Title
Int J Clin Oncol.
Volume: 19
Issue: 6
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Peer Reviewed
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[Journal Article] Monitoring the impact of a national HPV vaccination program in Japan (MINT study): rationale, design and methods.2014
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Matsumoto K, Yaegashi N, Iwata T, Ariyoshi K, Fujiwara K, Shiroyama Y, Usami T, Kawano Y, Horie K, Kawano K, Noda K, Yoshikawa H for MINT Study Group
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Journal Title
Jpn J Clin Oncol.
Volume: 44
Issue: 10
Pages: 1000-1003
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Peer Reviewed
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[Journal Article] Incidence of venous thromboembolism before treatment in cervical cancer and the impact of management on venous thromboembolism after commencement of treatment.2013
Author(s)
Toyomi Satoh, Koji Matsumoto, Yumiko O Tanaka, Azusa Akiyama, Sari Nakao, Manabu Sakurai, Hiroyuki Ochi, Mamiko Onuki, Takeo Minaguchi, Hideyuki Sakurai, Hiroyuki Yoshikawa.
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Journal Title
Thrombosis Research
Volume: 131(4)
Issue: 4
Pages: e127-e132
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Peer Reviewed
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[Journal Article] Phase III randomised controlled trial of neoadjuvant chemotherapy plus radical surgery vs radical surgery alone for stages IB2, IIA2, and IIB cervical cancer: a Japan Clinical Oncology Group trial (JCOG 0102).2013
Author(s)
Katsumata N, Yoshikawa H, Kobayashi H, Saito T, Kuzuya K, Nakanishi T, Yasugi T, Yaegashi N, Yokota H, Kodama S , Mizunoe T, Hiura M, Kasamatsu T, Shibata T, Kamura T
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Journal Title
Br J Cancer.
Volume: 108(10)
Issue: 10
Pages: 1957-1963
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[Journal Article] Loss of PTEN expression is an independent predictor of favourable survival in endometrial carcinomas.2013
Author(s)
Akiyama-Abe A, Minaguchi T, Nakamura Y, Michikami H, Shikama A, Nakao S, Sakurai M, Ochi H, Onuki M, Matsumoto K, Satoh T, Oki A, Yoshikawa H
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Journal Title
British Journal of Cancer
Volume: 109
Issue: 6
Pages: 1703-1710
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Peer Reviewed
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[Journal Article] Surgery for endometrial cancers with suspected cervical involvement: is radical hysterectomy needed (a GOTIC study)?2013
Author(s)
Takano M, Ochi H, Takei Y, Miyamoto M, Hasumi Y, Kaneta Y, Nakamura K, Kurosaki A, Satoh T, Fujiwara H, Nagao S, Furuya K, Yokota H, Ito K, Minegishi T, Yoshikawa H, Fujiwara K, Suzuki M.
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Journal Title
Br J Cancer
Volume: 109(7)
Issue: 7
Pages: 1760-1765
DOI
Related Report
Peer Reviewed
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[Presentation] Delivery delay with neoadjuvant chemotherapy for patients with FIGO stage Ib1 cervical cancer during pregnancy: A report of two cases.2014
Author(s)
Tenjimbayashi Y, Minaguchi T, Matsumoto K, Sakurai M, Onuki M, Ochi H, Obata M, Satoh T, Hamada H, Yoshikawa H.
Organizer
The 15th Biennial Meeting of the International Gynecologic Cancer Society
Place of Presentation
Melbourne, Australia,
Year and Date
2014-11-08 – 2014-11-11
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[Presentation] A cohort study of gastric-type adenocarcinoma (GAS) of the uterine cervix: Multi-institutional study by Gynecologic Cancer Study Group of the Japan Clinical Oncology Group (JCOG).2014
Author(s)
Nishio S, Mikami Y, Otsuki T, Yaegashi N, Satoh T, Yoshikawa H, Saito M, Okamoto A, Kasamatsu T, Miyamoto T, Shiozawa T, Yoshioka Y, Konishi I, Kojima A, Nogawa T, Kaneki E, Kobayashi H, Uhsijima K, Kamura T.
Organizer
50th Annual Meeting of American Society Of Clinical Oncology
Place of Presentation
Chicago, Illinois
Year and Date
2014-05-30 – 2014-06-03
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[Presentation] Comparison of treatment invasiveness between upfront debulking surgery versus interval debulking surgery following neoadjuvant chemotherapy for stage III/IV ovarian, tubal, and peritoneal cancers in phase III randomized trial: JCOG0602. ASCO 2014,2014
Author(s)
Onda T, Yoshikawa H, Shibata T, Nakamura K, Satoh T, Saito T, Kasamatsu T, Nakanishi T, Nogawa T, Saitou M, Ushijima K, Kobayashi H, Takano T, Kawana K, Yokota H, Takano M, Takeshima N, Yaegashi N, Konishi I, Kamura T, japan clinical Oncology Group.
Organizer
50th Annual Meeting of American Society Of Clinical Oncology
Place of Presentation
Chicago, Illinois
Year and Date
2014-05-30 – 2014-06-03
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[Presentation] Mutational status in the PI3K/AKT pathway and efficacy of mTOR inhibitors alone or combined with chemotherapeutics in ovarian clear cell carcinoma cells.2013
Author(s)
Minaguchi T, Akiyama A, Nakamura Y, Tasaka N, Yoahikawa T, Sakurai M, Ochi H, Onuki M, Matsumoto K, Satoh T, Oki A. Yoshikawa H.
Organizer
65th Annual Congress of the Japan Society of Obstetrics and Gynecology
Place of Presentation
Royton Sapporo,Sapporo Geibunkan,Sapporo Prince Hotel,Sapporo Education and Culture Hall(Sapporo)
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