| Project/Area Number |
25670746
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
OSAWA Masayuki 北海道大学, 医学(系)研究科(研究院), 客員研究員 (70625029)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yuhei 北海道大学, 大学院医学研究科, 教授 (70271674)
FURUKAWA Hiroshi 北海道大学, 大学院医学研究科, 准教授 (00399924)
OYAMA Akihiko 北海道大学, 北海道大学病院, 講師 (70374486)
FUNAYAMA Emi 北海道大学, 大学院医学研究科, 講師 (10533630)
HAYASHI Toshihiko 北海道大学, 大学院歯学研究科, 准教授 (00432146)
MURAO Naoki 北海道大学, 北海道大学病院, 助教 (90706558)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 再建外科学 / 顔面神経麻痺 |
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| Outline of Final Research Achievements |
This study demonstrated that the effect of neural reconstruction in rat models. In control group (group A), buccal branch was compressed by a ligature clip at peripheral to bifurcation of mandibular brunch and mandibular brunch was cut and ligated. In groups B, C and D, the nerve reconstruction was made in a different manner. The method of neurorrhaphy were ‘end-to-side’(group B), ‘side-to-side (large window)’(group C) and ‘side-to-side (small window)’(group D) technique. Facial palsy score was assessed every week. We measured the count of neural cells at the facial nucleus and axons at the distal point of neurorrhaphy.
The result showed that group B was equal to group C and group D was inferior to B and C, and group A was worst score in all groups.
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