Passive molecular separation system using microtubule transport
| Project/Area Number |
25709018
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Intelligent mechanics/Mechanical systems
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| Research Institution | Kyoto University |
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Principal Investigator |
Yokokawa Ryuji 京都大学, 工学(系)研究科(研究院), 准教授 (10411216)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 分子ロボティクス / ナノマシン / ナノバイオ / マイクロ・ナノフルイディクス / 生物物理 / 分子モーター / 分子操作 / 電気泳動 / マイクロ・ナノデバイス / MicroTAS / モータタンパク質 / ナノシステム / キネシン / 微小管 / MEMS |
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| Outline of Final Research Achievements |
The purpose of this study was to develop an autonomous molecular separation system using several different microtubules modified by molecular labeling. Short seed microtubules were modified with DNA to have different surface charge densities. Electrophoretic mobilities of seed microtubules were measured and their radius of gliding trajectories in an electric field was calculated. A microfluidic device was developed to separate two groups of microtubules. Results demonstrated the improved controllability of microtubule gliding directions driven by kinesin motors, which is applicable to molecular robotics.
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Report
(5 results)
Research Products
(60 results)
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[Journal Article] Synergistic effect of ATP for RuvA-RuvB-Holliday junction DNA complex formation.2015
Author(s)
Iwasa, T., Han, Y. W., Hiramatsu, R., Yokota, H., Nakao, K., Yokokawa, R., Ono, T., Harada, Y.
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 18177-18177
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] 電荷と曲げ剛性の同時改変による高精度な微小管分離2016
Author(s)
磯崎 直人, 新宅 博文, 小寺 秀俊, Hawkins Taviare L., Ross Jennifer L., 横川 隆司
Organizer
第33回「センサ・マイクロマシンと応用システム」シンポジウム
Place of Presentation
平戸
Year and Date
2016-10-24
Related Report
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[Presentation] 金薄膜と励起光照射による微小管速度制御技術2014
Author(s)
中原 佐, 生田 純也, 新宅 博文, 小寺 秀俊 , 横川 隆司
Organizer
平成26年度 電気学会E部門総合研究会 バイオ・マイクロシステム研究会
Place of Presentation
東京
Year and Date
2014-05-27 – 2014-05-28
Related Report
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[Presentation] 電界中での微小管運動曲率の定量的評価2013
Author(s)
磯崎 直人, 中原 佐, 安藤 駿, N. K. Kamisetty, 新宅 博文, 小寺 秀俊, E. Meyhofer, 横川 隆司
Organizer
第27回化学とマイクロ・ナノシステム研究会(27th Cheminas)
Place of Presentation
仙台市
Related Report
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