Establishment of nutrient renal medicine -lessoned from starvation-
Project/Area Number |
25713033
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Kidney internal medicine
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Research Institution | Shiga University of Medical Science |
Principal Investigator |
Kume Shinji 滋賀医科大学, 医学部, 助教 (00452235)
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Research Collaborator |
TAKAGI Ayano
YAMAHARA Mako
TAGAWA Atsuko
KUWAGATA Shogo
Ono Shinya
TANAKA Yuki
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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Keywords | 腎臓 / 飢餓 / 糖尿病性腎症 / mTORC1 / オートファジー / NAD代謝 / 糖鎖修飾 / マイクロRNA / 生理学 / 内科 / 栄養 / 脂肪酸 / 糸球体上皮細胞 / 尿細管細胞 |
Outline of Final Research Achievements |
This study revealed the novel physiological role of kidney to combat starvation. Renal autophagy is essential for hepatic and renal ketogenesis during starvation. Furthermore, we concluded that some renal nutrient-sensing signals and autophagy are associated with the pathogenesis of diabetic nephropathy. 1) Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes. 2) MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells. 3) Impaired podocyte- and proximal tubular cell-autophagy exacerbate proteinuria-related kidney injury in diabetic nephropathy. 4) 1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells. 5) O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes.
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Report
(5 results)
Research Products
(61 results)
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[Journal Article] O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes.2017
Author(s)
Ono S, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Chin-Kanasaki M, Araki H, Sekine O, Yokoi H, Mukoyama M, Uzu T, Araki SI, Maegawa H.
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Journal Title
Nephrol Dial Transplant.
Volume: 未定
Issue: 9
Pages: 000-000
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells.2016
Author(s)
Kuwagata S, Kume S, Chin-Kanasaki M, Araki H, Araki S, Nakazawa J, Sugaya T, Koya D, Haneda M, Maegawa H, Uzu T.
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Journal Title
Kidney Int.
Volume: 90
Issue: 6
Pages: 1211-1225
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation.2016
Author(s)
Takagi A, Kume S, Kondo M, Nakazawa J, Chin-Kanasaki M, Araki H, Araki S, Koya D, Haneda M, Chano T, Matsusaka T, Nagao K, Adachi Y, Chan L, Maegawa H, Uzu T.
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 18944-18944
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Impaired podocyte autophagy exacerbates proteinuria in diabetic nephropathy.2016
Author(s)
Tagawa A, Yasuda M, Kume S, Ymahara K, Nakazawa J, Chin-Kanasaki M, Araki H, Araki SI, Koya D, Asanuma K, Kim EH, Haneda M, Kajiwara N, Hayashi K, Ohashi H, Ugi S, Maegawa H, Uzu T
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Journal Title
Diabetes.
Volume: -
Issue: 3
Pages: 755-767
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] 1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells.2015
Author(s)
Tanaka Yuki, Kume Shinji, Araki Hisazumi, Nakazawa Jun, Chin-Kanasaki Masami, Araki Shin-ichi, Nakagawa Fumiyuki, Koya Daisuke, Haneda Masakazu, Maegawa Hiroshi, Uzu Takashi.
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Journal Title
Free Radic Biol Med.
Volume: 89
Pages: 831-841
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes.2014
Author(s)
Yasuda M, Tanaka Y, Kume S, Morita Y, Chin-Kanasaki M, Araki H, Isshiki K, Araki SI, Koya D, Haneda M, Kashiwagi A, Maegawa H, Uzu T.
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Journal Title
Biochim Biophys Acta.
Volume: 1842
Issue: 7
Pages: 1097-1108
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions.2013
Author(s)
Yamahara K, Kume S, Koya D, Tanaka Y, Morita Y, Chin-Kanasaki M, Araki H, Isshiki K, Araki S, Haneda M, Matsusaka T, Kashiwagi A, Maegawa H, Uzu T.
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Journal Title
J Am Soc Nephrol.
Volume: 24
Issue: 11
Pages: 1769-81
DOI
Related Report
Peer Reviewed
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[Presentation] 腎老化2016
Author(s)
久米真司
Organizer
第59回日本腎臓学会学術総会
Place of Presentation
横浜
Year and Date
2016-06-17
Related Report
Invited
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[Presentation] 糸球体上皮細胞におけるオートファジー不全は糖尿病性腎症における蛋白尿を増悪させる2015
Author(s)
田川 安都子, 安田 真子, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄,荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
Organizer
第58回日本腎臓学会学術総会
Place of Presentation
名古屋
Year and Date
2015-06-05
Related Report
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[Presentation] 糸球体上皮細胞の機能維持における蛋白O-GlcNAc修飾の役割2015
Author(s)
小野 真也, 安田 真子, 久米 真司, 関根 理, 中澤 純, 金崎 雅美, 荒木 久澄, 荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
Organizer
第58回日本糖尿病学会年次学術集会
Place of Presentation
下関
Year and Date
2015-05-21
Related Report
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[Presentation] Protein O-GlcNAcylation is essential for maintaining normal podocyte function2014
Author(s)
Shinya Ono, Mako Yasuda, Shinji Kume, Jun Nakazawa, Hisazumi Araki, Masami Chin-Kanasaki, Shin-ichi Araki, Daisuke Koya, Masakazu Haneda, Takashi Uzu, Hiroshi Maegawa
Organizer
American Society of Nephrology (Kidney Week 2014)
Place of Presentation
フィラデルフィア, アメリカ合衆国
Year and Date
2014-11-11 – 2014-11-16
Related Report
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[Presentation] Podocyte Autophagy is Associated with the Progression of Proteinuria in Diabetic Nephropathy2014
Author(s)
Mako Yasuda, Atsuko Tagawa, Shinji Kume, Yuki Tanaka, Kosuke Yamahara, Hisazumi Araki, Keiji Isshiki, Shin-ichi Araki, Daisuke Koya, Masakazu Haneda, Takashi Uzu and Hiroshi Maegawa
Organizer
American Diabetes Association (ADA) 74th Scientific Sessions
Place of Presentation
サンフランシスコ, アメリカ合衆国
Year and Date
2014-06-13 – 2014-06-17
Related Report
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[Presentation] 糸球体上皮細胞オートファジー不全は糖尿病性腎症における蛋白尿を増悪させる2014
Author(s)
安田 真子, 田川 安都子, 久米 真司, 田中 敬, 金崎 雅美, 荒木 久澄, 一色 啓二, 荒木 信一, 古家 大祐, 羽田 勝計, 柏木 厚典, 宇津 貴, 前川 聡
Organizer
第57回日本糖尿病学会年次学術集会
Place of Presentation
大阪
Year and Date
2014-05-22 – 2014-05-24
Related Report
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[Presentation] 飽和脂肪酸はmTORC1過剰亢進を介し糸球体上皮細胞のアポトーシスを惹起する.2013
Author(s)
安田 真子, 田中 敬, 久米 真司, 森田 善方, 荒木 久澄, 一色 啓二, 荒木 信一, 古家 大祐, 羽田 勝計, 柏木 厚典, 宇津 貴, 前川 聡.
Organizer
第28回日本糖尿病合併症学会
Place of Presentation
旭川
Related Report
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