Analysis of bone and cartilage destruction mechanism via RANKL/Fas signaling in rheumatoid arthritis
Project/Area Number |
25713063
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Orthodontics/Pediatric dentistry
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Research Institution | The University of Tokushima |
Principal Investigator |
IZAWA Takashi 徳島大学, 大学院医歯薬学研究部, 助教 (30380017)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2015: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2013: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
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Keywords | 歯学 / 歯科矯正学 / 免疫学 / 病理学 / 細胞・組織 / シグナル伝達 / 関節リウマチ / 破骨細胞 |
Outline of Final Research Achievements |
In this study, we investigated the functions of osteoclasts (OCs) from Fas-mutant MRL/lpr mice, murine model for rheumatoid arthritis (RA). In vitro and in vivo experiments showed hyperfunction of MRL/lpr OCs. Furthermore, the migratory response of MRL/lpr OC precursors to S1P was significantly enhanced. The hyper function of OCs in MRL/lpr mice play a potent role in the pathogenesis for RA with bone and cartilage destruction. Crosstalk between RANK/RANKL signaling and Fas/FasL signaling of OCs may regulate the differentiation and migratory function of OC precursors.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis2015
Author(s)
Izawa T., Rohatgi N., Fukunaga T., Wang Q.T., Silva M.J., Gardner M.J., McDaniel M.L., Abumrad N.A., Semenkovich C.F., Teitelbaum S.L., Zou W.
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Journal Title
Cell Rep.
Volume: 11
Issue: 10
Pages: 1625-1637
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] ASXL2 Regulates Skeletal, Glucose and Lipid Homeostasis2014
Author(s)
Nidhi Rohatgi, Takashi Izawa, Tomohiro Fukunaga, Qun-Tian Wang, Matthew Silva, Michael Gardner, Michael McDaniel, Clay Semenkovich, Wei Zou, Steven Teitelbaum
Organizer
American Society for Bone and Mineral Research 2014 Annual Meeting
Place of Presentation
Houston, Texas, USA
Year and Date
2014-09-12 – 2014-09-13
Related Report
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