Evaluation of the radiation dose exposure and chromosomal aberration on animals in radiation-contaminated areas.

• Project/Area Number: 25740026
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental impact assessment
• Research Institution: Hokkaido Pharmaceutical University School of Pharmacy (2014-2016); Hirosaki University (2013)
• Principal Investigator: Nakata Akifumi 北海道薬科大学, 薬学部, 講師 (70415420)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 野生動物 / 放射線 / 染色体 / DNA

Outline of Final Research Achievements

The objective of this study was to evaluate the effect of radioactive materials on the Japanese large field mouse, Apodemus speciosus, by analyzing age distribution, growth, exposure dose, and chromosome aberrations of mice.
The ratio of mice born before and after the F1-NPP accident was significantly low in the Fukushima population. However, our results showed that the population of mice in Fukushima has recovered. The growth of mice is not significantly different in examined areas. There were no radiation-specific chromosomal abnormalities in the mice examined. The external dose of mice in the evacuation area was lower than the air and soil dose rates. Although radiation doses in contaminated areas have been decreasing, exposure doses in mice had not decreased.

Research Products

• [Journal Article] Analysis of the Effect of Chronic and Low-Dose Radiation Exposure on Spermatogenic Cells of Male Large Japanese Field Mice (Apodemus speciosus ) after the Fukushima Daiichi Nuclear Power Plant Accident. (2016)
  • Author(s): Takino S, Yamashiro H, Sugano Y, Fujishima Y, Nakata A, Kasai K, Hayashi G, Urushihara Y, Suzuki M, Shinoda H, Miura T, Fukumoto M.
  • Journal Title: Radiat Res Volume: 187 Issue: 2 Pages: 161-168
  • DOI: 10.1667/rr14234.1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of seasonal changes on testicular morphology and the expression of circadian clock genes in Japanese wood mice (Apodemus speciosus) (2015)
  • Author(s): Akiyama M, Takino S, Sugano Y, Yamada T, Nakata A, Miura T, Fukumoto M, Yamashiro H
  • Journal Title: Journal of Biological Regulators & Homeostatic Agents Volume: 29 Pages: 589-600
  • Peer Reviewed
• [Journal Article] A novel parameter, cell-cycle progression index, for radiation dose absorbed estimation in the premature chromosome condensation assay (2014)
  • Author(s): Miura T, Nakata A, Kasai K, Nakano M, Abe Y, Tsushima E, Ossetrova NI, Yoshida MA, Blakely WF
  • Journal Title: radiat Prot Dosimetry Volume: 159 Issue: 1-4 Pages: 1-4
  • DOI: 10.1093/rpd/ncu126
  • Peer Reviewed
• [Journal Article] Healthcare of 18 Workers who Supported the Regulation of Radiological Contaminations at the Fukushima Daiichi Nuclear Power Plant (2013)
  • Author(s): Miura T, Nakata A, Kasai K, Abe Y, Jin Y, Yoshida MA
  • Journal Title: Radiation Emergency Medicine Volume: 2 Pages: 63-67
  • NAID: 40019745115
  • Peer Reviewed
• [Journal Article] Activity concentrations of environmental samples collected in Fukushima Prefecture immediately after the Fukushima nuclear accident. (2013)
  • Author(s): M. Hosoda, S. Tokonami, H. Tazoe, A. Sorimachi, S. Monzen, M. Osanai, N. Akata, H. Kakiuchi, Y. Omori, T. Ishikawa, S. K. Sahoo, T. Kovacs, M. Yamada, A. Nakata, M. Yoshida, H. Yoshino, Y. Mariya, I. Kashiwakura.
  • Journal Title: Scientific Reports Volume: 3:2283 Issue: 1 Pages: 1-6
  • DOI: 10.1038/srep02283
  • Peer Reviewed
• [Journal Article] Co-operative effects of thoracic X-ray irradiation and N-nitrosobis (2-hydroxypropyl) amine administration on lung tumorigenesis in neonatal, juvenile and adult Wistar rats (2013)
  • Author(s): Iwata KI, Yamada Y, Nakata A., Oghiso Y, Tani S, Doi K, Morioka T, Blyth BJ, Nishimura M, Kakinuma S, Shimada Y
  • Journal Title: Toxicology and Applied Pharmacology Volume: 267 Issue: 3 Pages: 266-25
  • DOI: 10.1016/j.taap.2012.12.024
  • Peer Reviewed
• [Journal Article] Thyroid screening survey on children after the Fukushima Daiichi nuclear power plant accident (2013)
  • Author(s): Hosokawa Y, Hosoda M, Nakata A, Kon M, Urushizaka M, Yoshida MA
  • Journal Title: Radiation Emergency Medicine Volume: 2 Pages: 82-86
  • NAID: 40019561921
  • Peer Reviewed
• [Presentation] 未成（早期）熟凝縮染色体（PCC）法とFISH法を併用した二動原体染色体線量推定法の検討 (2016)
  • Author(s): 氏家里紗、藤嶋洋平、阿部 悠、中田章史、葛西宏介、三浦富智、津山尚宏、有吉健太郎、吉田光明、坂井晃
  • Organizer: 日本放射線影響学会第59大会
  • Place of Presentation: 広島市
  • Year and Date: 2016-10-26
• [Presentation] 福島県浪江町におけるネコの内部被ばく解析 (2016)
  • Author(s): 藤嶋洋平，中田章史，三浦富智，田副博文，豊田正，葛西宏介，有吉健太郎，山田正俊，吉田光明
  • Organizer: 日本放射線影響学会第59大会
  • Place of Presentation: 広島市
  • Year and Date: 2016-10-26
• [Presentation] 放射性物質汚染地域に生息するノネズミの被ばく線量推定法の開発 (2016)
  • Author(s): 中田章史、藤嶋洋平、葛西宏介、有吉健太郎、斎藤幹男、鈴樹亨純、三浦富智、吉田光明、福本学
  • Organizer: 日本放射線影響学会第59大会
  • Place of Presentation: 広島市
  • Year and Date: 2016-10-26
• [Presentation] 放射線誘発悪性腫瘍の発生に関与する染色体異常の解析 (2016)
  • Author(s): 有吉健太郎、中田章史、藤嶋洋平、三浦富智、葛西宏介、尚奕、柿沼志津子、島田義也、立花章、吉田光明
  • Organizer: 日本放射線影響学会第59大会
  • Place of Presentation: 広島市
  • Year and Date: 2016-10-26
• [Presentation] 電子線マイクロアナライザによる被災アカネズミ精巣の元素分析 (2016)
  • Author(s): 大平拓也, 伊藤 洵, 藤嶋洋平, 菅原淳史,山城秀昭,中田章史, 鈴木正敏, 有吉健太郎, 葛西宏介, 篠田壽, 三浦富智, 福本学
  • Organizer: 日本放射線影響学会第59大会
  • Place of Presentation: 広島市
  • Year and Date: 2016-10-26
• [Presentation] 低分子化ライチポリフェノールのメタボリックシンドロームモデルマウス肝臓の遺伝子に与える影響の網羅的解析 (2016)
  • Author(s): 廣瀬浩平、若命浩二、小松健一、中田章史、佐藤恵亮、高成準、佐藤敦哉、上原佳織、内山博允、長島孝行
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-03-26
• [Presentation] ライチ低分子化ポリフェノール（オリゴノール）のメタボリックシンドロームモデルマウスに対する効果 (2015)
  • Author(s): 上原佳織、若命浩二、小松健一、佐藤恵亮、中田章史、長島孝行、内山博允、高成準、三浦健人
  • Organizer: 第19回バイオ治療法研究会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2015-12-05
• [Presentation] C3H/HeNマウスに対するLPS、松樹皮エキスの育毛効果の検討 (2015)
  • Author(s): 若命浩二、小松健一、中田章史、大川博、杣源一郎、稲川裕之、西澤孝志
  • Organizer: 第47回自然免疫賦活技術研究会
  • Place of Presentation: 高松市
  • Year and Date: 2015-06-19
• [Presentation] Radiation dosimetry for the internal exposure of the cats in Namie- town. (2015)
  • Author(s): Fujishima Y, Nakata A, Miura T, Tazoe H, Toyoda T, Kasai K, Ariyoshi K, Yamada M, Konno N, Yoshida MA
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Assessment of Simulated Partial Body Acute Irradiation by Cell-cycle Progression Index in the Premature Chromosome Condensation Assay. (2015)
  • Author(s): Miura T, Abe Y, Nakata A, Kasai K, Yoshida MA
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Effects of radioactive pollution of the Japanese large field mouse (Apodemus specious) in Fukushima. (2015)
  • Author(s): Nakata A, Fujishima Y, Ujiie R, Kasai K, Tazoe H, Ariyoshi K, Saito M, Suzuki K, Yamada M, Miura T, Yoshida MA, Fukumoto M
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] 放射性物質汚染地域に生息するアカネズミの生物影響解析 (2014)
  • Author(s): 三浦富智、中田章史、藤嶋洋平、氏家里紗、葛西宏介、田副博文、有吉健太郎、齋藤幹男、鈴樹亨純、山田正俊、吉田光明、福本学
  • Organizer: 日本放射線影響学会第57回大会
  • Place of Presentation: 鹿児島市
  • Year and Date: 2014-10-01 – 2014-10-03
• [Presentation] 被災アカネズミの雄性生殖細胞における増殖能の評価 (2014)
  • Author(s): 瀧野祥生、トウビン、菅野有晃、岩島玲奈、秋山将、中田章史、葛西宏介、三浦富智、福本学、山城秀昭
  • Organizer: 日本放射線影響学会第57回大会
  • Place of Presentation: 鹿児島市
  • Year and Date: 2014-10-01 – 2014-10-03
• [Presentation] 炭素線で誘発させたマウス胸腺リンパ腫の仔マウスにおける染色体異常の特徴 (2014)
  • Author(s): 吉田光明、中田章史、藤嶋洋平、高橋千佳、外館茜、有吉健太郎、柿沼志津子、島田義也
  • Organizer: 日本放射線影響学会第57回大会
  • Place of Presentation: 鹿児島市
  • Year and Date: 2014-10-01 – 2014-10-03
• [Presentation] ヒト末梢血ex vivo部分照射モデルにおけるCell-cycle Progression Indexの有用性評価 (2014)
  • Author(s): 三浦富智、阿部悠、中田章史、葛西宏介、吉田光明
  • Organizer: 日本放射線影響学会第57回大会
  • Place of Presentation: 鹿児島市
  • Year and Date: 2014-10-01 – 2014-10-03
• [Presentation] Radiation dosimetry for the internal exposure of the cats in Namie-Town (2014)
  • Author(s): Fujishima Y, Nakata A, Miura T, Tazoe H, Toyoda T, Kasai K, Ariyoshi K, Yamada M, Konno N, Yoshida MA
  • Organizer: The 9th International Symposium on the Natural Radiation Environment (NRE-IX)
  • Place of Presentation: 弘前市
  • Year and Date: 2014-09-21 – 2014-09-22
• [Presentation] 被災アカネズミにおける精巣の形態学的観察 (2013)
  • Author(s): 瀧野祥生，Tong Bin，岩島玲奈，柳沼日佳里，中田章史，葛西宏介，三浦富智，福本学，山城秀昭
  • Organizer: 北信越畜産学会第62回大会
  • Place of Presentation: 金沢市
• [Presentation] 放射性物質汚染地域におけるアカネズミの個体群調査 (2013)
  • Author(s): 吉田光明，藤嶋洋平，氏家里紗，葛西宏介，三浦富智，対馬栄輝，鈴樹亨純，中田章史
  • Organizer: 日本放射線影響学会第５６回大会
  • Place of Presentation: 青森市
• [Presentation] 福島第一原発被災地域に棲息する野生アカネズミの歯の線量解析 (2013)
  • Author(s): 篠田壽，木野康志，中田章史，葛西宏介，高橋温，清水良央，鈴木敏彦，千葉美麗，関根勉，福本学，三浦富智
  • Organizer: 日本放射線影響学会第５６回大会
  • Place of Presentation: 青森市
• [Presentation] 福島県浪江町の被災住民における染色体転座解析のためのシステム構築 (2013)
  • Author(s): 中田章史，吉田光明，三浦富智，西村美八，高間木静香，葛西宏介，紺野則夫，吉田良子，関根俊二
  • Organizer: 日本放射線影響学会第５６回大会
  • Place of Presentation: 青森市
• [Presentation] 土壌中の放射能比分析による福島第一原子力発電所事故由来のプルトニウムの飛散状況の把握
  • Author(s): 山口朋子、山田正俊、田副博文、葛西宏介、中田章史、細川洋一郎
  • Organizer: 平成２５年度青森県放射線技師学術大会
  • Place of Presentation: 弘前市