Long term exposure to transboundary air pollution including Asian dust storm airborne particles may potentiate carcinogenesis

Research Project

Project/Area Number	25740028
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Environmental impact assessment
Research Institution	Tottori University
Principal Investigator	KURAI Jun 鳥取大学, 医学部附属病院, 助教 (70529396)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	黄砂 / 長期曝露 / 炎症発癌 / 越境大気汚染
Outline of Final Research Achievements	The objective of this study is to examine the association of carcinogenesis with long term exposure of Asian dust storm (ADS) airborne particles in vitro. Our data showed that ADS airborne particles exposure to cultured tracheal epithelial cells induced inflammatory cytokines and oxidative stress within a relatively short time. These data imply a potentially important role for link between carcinogenesis and ADS airborne particles exposure. We also initiated studies aimed at analyzing the element of human lung tissue samples which was derived from lung cancer patients in West Japan. Tissue samples of smoking and never-smoking patients were analyzed by the X-ray fluorescence spectrometry method. We could not detect the difference of element distribution between smokers and never-smokers about the non-soil component attached on ADS airborne particle. Further studies are needed to reveal the adverse health effect of long term exposure for human lung tissue.