The mechanisms by which physical exercise regulates insulin action in liver

• Project/Area Number: 25750337
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Niigata University of Health and Welfare
• Principal Investigator: Koshinaka Keiichi 新潟医療福祉大学, 健康科学部, 講師 (30468037)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 肝臓 / 熱刺激 / ヘパトカイン / 身体運動 / インスリン作用 / インスリン抵抗性 / 運動

Outline of Final Research Achievements

Regular physical exercise enhances insulin action not only in exercised muscles but also in liver. However, it not clear the mechanisms by which exercise regulates liver adaptations.
In this study, I have revealed that repeated heat stimulation on rat hindlimbs, with heat diffusion to liver, led to adaptations in the liver as observed in regularly exercised subjects. This result indicates that heat production in exercised muscle and its diffusion to liver have important role in liver adaptations in response to exercise.