Analysis on mechanism of postprandial hyperglycemia mediated caveolin-1 expression and establishment of strategy for improving postprandial hyperglicemia

• Project/Area Number: 25750365
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Kindai University
• Principal Investigator: NAKAMURA Kyoko 近畿大学, 薬学総合研究所, 講師 (10512197)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 食後高血糖 / caveolin-1 / GLP-1受容体

Outline of Final Research Achievements

Postprandial hyperglycemia is transiently increased blood glucose levels that occur soon after the meal, although fasting blood glucose is normal or boundary range. Thus, it is possible that postprandial hyperglycemia cannot be detected by medical checkup that usually tested fasting blood glucose. We considered that this is one of the causes of the increased diabetic patients and analyzed the mechanism in developing postprandial hyperglycemia. As a results, the hepatic caveolin-1 was decreased and hepatic GLP-1 receptor expression was increased in the ob/ob diabetic model mice at 1 hour after a meal. These results indicated that the GLP-1 receptor dysfunction was associated with the mechanism involved in the development of postprandial hyperglycemia.