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Multi-scale modeling of blood cell membrane and clarification of adhesion phenomenon

Research Project

Project/Area Number 25790097
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Computational science
Research InstitutionOsaka University

Principal Investigator

Ii Satoshi  大阪大学, 基礎工学研究科, 助教 (50513016)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords血球 / マルチフィジックス / 連成解析 / 二層膜 / 半透膜 / 浸透圧 / 接着力推定 / 脂質膜 / スペクトリン / 滑り / 面積抵抗 / マルチスケール
Outline of Final Research Achievements

In this study, in order to reveal dynamic behaviors of blood cell in adhesion and high shear flow, we have proposed: 1) two-layer membrane model including slipping between lipid bilayer and spectrin network phase; 2) formulation for osmotic swelling and shrinking of a capsule with a semi-permeable membrane; 3) inverse analysis model for evaluation of adhesion force in an experiment. We have uncovered that, in high shear flow, slipping velocity apparently and locally appears on the membrane, and local difference of the membrane force affects the osmotic behavior of the blood cell. Moreover, we have showed a feasibility of the inverse analysis of adhesion force evaluation in experiments that includes a three deformation field.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2016 2014 2013 Other

All Journal Article (2 results) Presentation (5 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] 深さ展開モデルを用いた細胞牽引力の逆解析2016

    • Author(s)
      伊井仁志,坂元尚哉,和田成生
    • Journal Title

      第28回バイオエンジニアリング講演会講演論文集

      Volume: No.15-69

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 透過性を有する弾性膜カプセルの変形と濃度輸送の連成解析手法の提案2013

    • Author(s)
      伊井 仁志、和田 成生
    • Journal Title

      日本機械学会第26回計算力学講演会(CD-ROM)

      Volume: No.13-3

    • Related Report
      2013 Research-status Report
  • [Presentation] 深さ展開モデルを用いた細胞牽引力の逆解析2016

    • Author(s)
      伊井仁志,坂元尚哉,和田成生
    • Organizer
      日本機械学会第28回バイオエンジニアリング講演会
    • Place of Presentation
      東京工業大学大岡山キャンパス(東京・目黒)
    • Year and Date
      2016-01-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 固定格子を用いた連成解析手法の提案と生体力学問題への適用2014

    • Author(s)
      伊井 仁志
    • Organizer
      第4回計算力学シンポジウム
    • Place of Presentation
      日本学術会議講堂(東京都、港区)
    • Year and Date
      2014-12-01
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] A numerical simulation of an osmotically-swollen/shrunk red blood cell2014

    • Author(s)
      伊井 仁志,和田 成生
    • Organizer
      7th World Congress of Biomechanics
    • Place of Presentation
      The John B. Hynes Veterans Memorial Convention Center, Boston, MA, USA.
    • Year and Date
      2014-07-06 – 2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] An immersed boundary method for simulating the osmotic swelling and shrinking of a liquid-filled capsule with semi-permeable membrane2014

    • Author(s)
      伊井 仁志,和田 成生
    • Organizer
      COMPSAFE 2014
    • Place of Presentation
      Sendai International Center, Sendai, Miyagi
    • Year and Date
      2014-04-13 – 2014-04-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 透過性を有する弾性膜カプセルの変形と濃度輸送の連成解析手法の提案2013

    • Author(s)
      伊井 仁志、和田 成生
    • Organizer
      日本機械学会第26回計算力学講演会
    • Place of Presentation
      佐賀大学大学院工学系研究科(佐賀市本庄町1番地)
    • Related Report
      2013 Research-status Report
  • [Remarks] 浸透圧による変形カプセルの挙動解析

    • URL

      https://sites.google.com/site/biomechwadalab/yan-jiu-shao-jie/jin-tou-yaniyoru-bian-xingkapuseruno-ju-dong-jie-xi

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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