| Project/Area Number |
25810022
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 不斉有機触媒 / フッ素化反応 / 有機触媒 / フッ素 / 生理活性物質 |
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| Outline of Final Research Achievements |
This research mainly focused on the development of new hydrazine organocatalysts designed for multisubstituted aldehydes. First, we planned the synthesis of desired hydrazine organocatalysts, however the original design of the target compound was revealed unstable, and required for redesigning the structure. Additionally, the selection of substituted aldehydes was investigated for direct fluorination with new and reported organocatalysts. Among four structurally different unsaturated aldehydes, two showed promising results for highly stereoselective and enantioselective reactions, which can apply for the synthesis of now building blocks for fluorinated bioactive compounds.
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