The clinical utility for IHC ki67 after pre-operative short term hormone therapy

• Project/Area Number: 25830101
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnostics
• Research Institution: Okayama University
• Principal Investigator: IWAMOTO Takayuki 岡山大学, 医学部, 客員研究員 (40627238)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 乳癌 / バイオマーカー / 遺伝子マーカー / 免疫染色Ki67 / 術前短期ホルモン療法 / 術前療法 / ホルモン療法 / IHC Ki67 / サンプル収集 / 学会参加 / 術前短期ホルモン / 遺伝子プロファイリング

Outline of Final Research Achievements

Recently, IHC Ki67 after short-term hormone therapy is one of the hot topics to omit unnecessary chemotherapy for hormone receptor positive breast cancers. However, its biological processes have not been unknown.
In this study we are under investigating IHC Ki67 and genomic profiling before and after short-term hormone therapy. So far, we have completed the collection of samples and immunological study. However, it will take another time to perform profiling of samples, because of maintenance of equipment, failure, etc. After the new research collaborations with Tokushima University will be allowed by the clinical trials committee at our institution, we will resume the profiling of samples. The results will be coming.

Research Products

• [Journal Article] Estrogen receptor (ER) mRNA expression and molecular subtype distribution in ER-negative/progesterone receptor-positive breast cancers (2013)
  • Author(s): Mitsuya Itoh; Takayuki Iwamoto; Junji Matsuoka; Tomohiro Nogami; Takayuki Motoki; Tadahiko Shien; Naruto Taira; Naoki Niikura; Naoki Hayashi; Shoichiro Ohtani; Kenji Higaki; Toshiyoshi Fujiwara; Hiroyoshi Doihara; W. Fraser Symmans; Lajos Pusztai
  • Journal Title: Breast Cancer Res Treat Volume: 143(2) Issue: 2 Pages: 403-9
  • DOI: 10.1007/s10549-013-2763-z
  • NAID: 120005469525
  • Peer Reviewed
• [Journal Article] TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase (2013)
  • Author(s): Xiaoping Wang, Hitomi Saso, Takayuki Iwamoto, Weiya Xia, Yun Gong, Lajos Pusztai, Wendy A. Woodward, James M. Reuben, Steven L. Warner, David J. Bearss, Gabriel N. Hortobagyi, Mien-Chie Hung, Naoto T. Ueno
  • Journal Title: Cancer Res Volume: 73(21)
  • Peer Reviewed
• [Journal Article] Uncovering the molecular secrets of Inflammatory Breast Cancer biology: An integrated analysis of three distinct Affymetrix gene expression data sets (2013)
  • Author(s): Steven J. Van Laere, Naoto T. Ueno, Pascal Finetti, Peter Vermeulen, Anthony Lucci, Fredika M. Robertson, Melike Marsan, Takayuki Iwamoto, Savitri Krishnamurthy, Hiroko Masuda, Peter van Dam, Wendy A. Woodward, Patrice Viens, Massimo Cristofanilli, Daniel Birnbaum, Luc Dirix, James M. Reuben, and François Bertucci
  • Journal Title: Clinical cancer reserach Volume: 1;19(17) Pages: 4685-96
• [Journal Article] Bayesian Mixture Models for Assessment of Gene Differential Behaviour and Prediction of pCR through the Integration of Copy Number and Gene Expression Data (2013)
  • Author(s): Trentini, F. Ji, Y. Iwamoto, T. Qi, Y. Pusztai, L. Muller, P.
  • Journal Title: PLoS One Volume: 8 Issue: 7 Pages: e68071-e68071
  • DOI: 10.1371/journal.pone.0068071
  • Peer Reviewed
• [Journal Article] A 3-gene proliferation score (TOP-FOX-67) can re-classify histological grade-2, ER-positive breast cancers into low- and high-risk prognostic categories (2013)
  • Author(s): Szekely, B. Iwamoto, T. Szasz, A. M. Qi, Y. Matsuoka, J. Symmans, W. F. Tokes, A. M. Kulka, J. Swanton, C. Pusztai, L.
  • Journal Title: Breast Cancer Res Treat Volume: 138 Issue: 3 Pages: 691-8
  • DOI: 10.1007/s10549-013-2475-4
  • Peer Reviewed
• [Journal Article] DNA repair gene patterns as prognostic and predictive factors in molecular breast cancer subtypes (2013)
  • Author(s): Santarpia, L. Iwamoto, T. Di Leo, A. Hayashi, N. Bottai, G. Stampfer, M. Andre, F. Turner, N. C. Symmans, W. F. Hortobagyi, G. N. Pusztai, L. Bianchini, G.
  • Journal Title: Oncologist Volume: 18 Issue: 10 Pages: 1063-73
  • DOI: 10.1634/theoncologist.2013-0163
  • Peer Reviewed
• [Journal Article] Women prefer adjuvant endocrine therapy to chemotherapy for breast cancer treatment (2013)
  • Author(s): Niikura, N. Kimura, M. Iwamoto, T. Hayashi, N. Shintoku, J. Saito, Y. Suzuki, Y. Tokuda, Y.
  • Journal Title: Breast Cancer Volume: 20 Issue: 1 Pages: 67-74
  • DOI: 10.1007/s12282-011-0310-5
  • NAID: 10031164583
  • Peer Reviewed
• [Journal Article] Long-term treatment efficacy in primary inflammatory breast cancer by hormonal receptor- and HER2-defined subtypes (2013)
  • Author(s): Masuda, H. Brewer, T. M. Liu, D. D. Iwamoto, T. Shen, Y. Hsu, L. Willey, J. S. Gonzalez-Angulo, A. M. Chavez-Macgregor, M. Fouad, T. M. Woodward, W. A. Reuben, J. M. Valero, V. Alvarez, R. H. Hortobagyi, G. N. Ueno, N. T.
  • Journal Title: Ann Oncol Volume: 25(2) Issue: 2 Pages: 384-91
  • DOI: 10.1093/annonc/mdt525
  • Peer Reviewed
• [Journal Article] Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers (2013)
  • Author(s): Masuda, H. Baggerly, K. A. Wang, Y. Iwamoto, T. Brewer, T. Pusztai, L. Kai, K. Kogawa, T. Finetti, P. Birnbaum, D. Dirix, L. Woodward, W. A. Reuben, J. M. Krishnamurthy, S. Symmans, W. F. Van Laere, S. J. Bertucci, F. Hortobagyi, G. N. Ueno, N. T.
  • Journal Title: Breast Cancer Res Volume: 15 Issue: 6
  • DOI: 10.1186/bcr3579
  • Peer Reviewed
• [Journal Article] Ink4a/Arf(-/-) and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f(-) quiescent cells (2013)
  • Author(s): Kai, K. Iwamoto, T. Kobayashi, T. Arima, Y. Takamoto, Y. Ohnishi, N. Bartholomeusz, C. Horii, R. Akiyama, F. Hortobagyi, G. N. Pusztai, L. Saya, H. Ueno, N. T.
  • Journal Title: Oncogene Volume: 23;33(4) Pages: 440-8
  • Peer Reviewed
• [Journal Article] Clinical benefit from neoadjuvant chemotherapy in oestrogen receptor-positive invasive ductal and lobular carcinomas (2013)
  • Author(s): Delpech, Y. Coutant, C. Hsu, L. Barranger, E. Iwamoto, T. Barcenas, C. H. Hortobagyi, G. N. Rouzier, R. Esteva, F. J. Pusztai, L.
  • Journal Title: Br J Cancer Volume: 108 Issue: 2 Pages: 285-91
  • DOI: 10.1038/bjc.2012.557
  • Peer Reviewed
• [Journal Article] Statin use in primary inflammatory breast cancer: a cohort study (2013)
  • Author(s): Brewer, T. M. Masuda, H. Liu, D. D. Shen, Y. Liu, P. Iwamoto, T. Kai, K. Barnett, C. M. Woodward, W. A. Reuben, J. M. Yang, P. Hortobagyi, G. N. Ueno, N. T.
  • Journal Title: Br J Cancer Volume: 109 Pages: 318-24
  • Peer Reviewed
• [Journal Article] Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers (2013)
  • Author(s): Bianchini, G. Pusztai, L. Karn, T. Iwamoto, T. Rody, A. Kelly, C. M. Muller, V. Schmidt, M. Qi, Y. Holtrich, U. Becker, S. Santarpia, L. Fasolo, A. Del Conte, G. Zambetti, M. Sotiriou, C. Haibe-Kains, B. Symmans, W. F. Gianni, L.
  • Journal Title: Breast Cancer Res Volume: 15 Issue: 5
  • DOI: 10.1186/bcr3481
  • Peer Reviewed
• [Journal Article] Gene expression profiles of inflammatory breast cancer: correlation with response to neoadjuvant chemotherapy and metastasis-free survival (2013)
  • Author(s): Bertucci, F. Ueno, N. T. Finetti, P. Vermeulen, P. Lucci, A. Robertson, F. M. Marsan, M. Iwamoto, T. Krishnamurthy, S. Masuda, H. Van Dam, P. Woodward, W. A. Cristofanilli, M. Reuben, J. M. Dirix, L. Viens, P. Symmans, W. F. Birnbaum, D. Van Laere, S. J.
  • Journal Title: Ann Oncol Volume: 25 Issue: 2 Pages: 358-65
  • DOI: 10.1093/annonc/mdt496
  • Peer Reviewed
• [Presentation] HER2陽性乳がんにおける免疫関連遺伝子のバイオマーカーとしての可能性: 2,091例の検討 (2013)
  • Author(s): 岩本高行、松岡順治、新倉直樹、林直輝、河田健吾、 鳩野みなみ 、伊藤麻衣子、西山慶子、溝尾妙子、野上智弘、 元木崇之、枝園忠彦、平成人、藤原俊義、土井原博義、Giampaolo Bianchini
  • Organizer: 日本乳癌学会学術総会
  • Place of Presentation: 浜松
• [Presentation] ER陰性/PR陽性乳がんにおけるER mRNAの発現とMolecularサブタイプ (2013)
  • Author(s): 岩本高行、松岡順治、鳩野みなみ、伊藤麻衣子、溝尾妙子、野上智弘、元木崇之、枝園忠彦、平成人、林直輝、新倉直樹、藤原俊義、土井原博義
  • Organizer: 第51回 日本癌治療学会学術集会
  • Place of Presentation: 京都
• [Presentation] Estrogen receptor (ER) mRNA expression and molecular subtype distribution in breast cancers that are ER-negative but progesterone receptor-positive by immunohistochemistory (2013)
  • Author(s): Takayuki Iwamoto, Junji Matsuoka, Tomohiro Nogami, Takayuki Motoki, Tadahiko Shien, Naruto Taira, Naoki Niikura, Naoki Hayashi, Toshiyoshi Fujiwara, Hiroyoshi Doihara, W Fraser Symmans, Lajos Pusztai
  • Organizer: San Antonio breast cancer symposium
  • Place of Presentation: San Antonio, USA