Development of prophylactic method and clarification of mechanism for anti-tumor drug-induced vascular pain by using approach both basic and clinical studies

• Project/Area Number: 25860109
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Kanazawa University
• Principal Investigator: SUGA YUKIO 金沢大学, 薬学系, 助教 (00467101)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 血管痛 / オキサリプラチン / ゲムシタビン / がん薬物療法 / 副作用管理 / TRPA1 / 血管痛の抑制 / 単位時間当たりの投与量 / 血管痛評価モデル / 投与液pH

Outline of Final Research Achievements

Vascular pain induced by administration of gemcitabine (GEM) or oxaliplatin (L-OHP) via peripheral venous is major problem in patients received cancer chemotherapy. To elucidate the mechanism of vascular pain will be required before prophylactic methods are established in clinical setting. The purpose of this study was to develop a useful prophylactic method for vascular pain in clinical setting and to clarify the inciting factor of pain that occur around the injection site or peripheral vein by using approach both basic and clinical studies. The results in this study suggested that vascular pain is depend on the dosage per unit of time, resulting from that extending the administration time of GEM or L-OHP could reduce the intensity of vascular pain and the mechanism of vascular pain could differ from agents associated with this pain.

Research Products

• [Presentation] オキサリプラチンによる血管痛の予防対策の評価および危険因子の解析 (2015)
  • Author(s): 池田菜々，菅 幸生，前田真奈美，岡田守弘，桂 英之，北出鉱規，米澤美和，石﨑純子，嶋田 努，柏原宏暢，崔 吉道，松下 良
  • Organizer: 日本医療薬学会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2015-11-21
• [Presentation] オキサリプラチン溶液の浸透圧が血管痛におよぼす影響 (2014)
  • Author(s): 前田真奈美，菅幸生，他
  • Organizer: 日本医療薬学会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-09-27 – 2014-09-28
• [Presentation] 生理的条件以下の投与液浸透圧とオキサリプラチンによる血管痛の関連 (2014)
  • Author(s): 菅幸生，他6名
  • Organizer: 日本臨床腫瘍学会
  • Place of Presentation: 福岡
  • Year and Date: 2014-07-17 – 2014-07-19