S-Nitrosated human serum albumin dimer as novel nano EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes
| Project/Area Number |
25860118
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
ISHIMA Yu 熊本大学, 薬学部, 助教 (00457590)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ヒト血清アルブミン / 一酸化窒素 / 癌 / EPR効果 / ドキシル / アブラキサン |
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| Outline of Final Research Achievements |
The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid tumors, and it can serve as a basis for the development of macromolecular anticancer therapy. We have previously found that recombinant human serum albumin dimer, and especially its S-nitrosated form (SNO-HSA-Dimer), is an enhancer of the EPR effect. In this study, we investigated the influence of SNO-HSA-Dimer on the anti-tumor effect of two types of macromolecular anti-tumor drugs. In mice having C26 tumors with highly permeable vasculature, SNO-HSA-Dimer increases tumor accumulation of the drugs by a factor 3-4 and thereby their anti-tumor effects. Furthermore, SNO-HSA-Dimer improves the anti-metastatic effects of Doxil and reduces its minor uptake in non-tumerous organs such as liver and kidney. The present findings indicate that SNO-HSA-Dimer is promising for enhancing the EPR effect and consequently the specific, therapeutic effects of macromolecular anticancer drugs.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Tuning of Poly-S-Nitrosated Human Serum Albumin as Superior Antitumor Nanomedicine2014
Author(s)
Ishima Y, Fang J, Kragh-Hansen U, Yin H, Liao L, Katayama N, Watanabe H, Kai T, Suenaga A, Maeda H, Otagiri M, Maruyama T
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Journal Title
J Pharm Sci
Volume: 103
Issue: 7
Pages: 2184-2188
DOI
Related Report
Peer Reviewed
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[Journal Article] Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases2014
Author(s)
K. Nagumo, M. Tanaka, VT. Chuang, H. Setoyama, H. Watanabe, N. Yamada, K. Kubota, M. Tanaka, K. Matsushita, A. Yoshida, H. Jinnouchi, M. Anraku, D. Kadowaki, Y. Ishima, Y. Sasaki, M. Otagiri, T. Maruyama.
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Journal Title
PLoS One
Volume: 9
Issue: 1
Pages: e85216-e85216
DOI
Related Report
Peer Reviewed / Open Access
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