| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Abnormal mitochondrial distribution and aggregation at perinuclear region in neuronal cells became to be recognized as one of the cause of neurodegenerative disease. We previously reported that deletion mutants of prion protein localize to
mitochondria and induce mitochondrial aggregation. In addition, we showed that 14-3-3 zeta is essential for mitochondrial aggregation. In this study, we found that 14-3-3 gamma, eta and Tom70 are also involved in mitochondrial aggregation evoked by prion protein.
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